Special Issue "Marine-Derived Biomolecules"
Deadline for manuscript submissions: closed (15 May 2020).
Interests: natural products chemistry; biomolecules; structure determination; antitumor and antibiotics of marine origin; microbial natural products; drug discovery; biotechnology; symbiosis in marine organisms; marine toxins; macromolecules of marine origin; chitin
The world’s Oceans have been shown to provide a rich place with great biodiversity and chemical entities with proven bioactivities related to cancer, inflammation, epilepsy, the immunomodulatory system, microbial and parasitic infections, and many others. Currently, there are eight approved drugs of marine origin and more than 22 other chemical entities in different clinical phases. Marine invertebrates and micro-organisms represent the major sources for these compounds.
The advantages of studying organisms from the marine environment lie primarily in the breadth of marine biodiversity and the consequent variety of new chemical structures found among marine natural products. Attesting to the tremendous diversity of marine life is the fact that of the 33 animal phyla, 32 are found in the sea, while only 12 occur on land. The larger genetic pool found in the marine environment has resulted in the synthesis of a wide variety of chemicals that can be exploited in a systematic screening program. Many of the primitive phyla that have evolved over the greatest time in the sea appear to have done so using survival mechanisms based on chemical synthesis. The compounds that are responsible for the successful survival of marine organisms possess significant biological activities that often interfere with the essential growth or biosynthetic mechanisms of competing organisms. These are precisely the types of chemicals that might be expected to be active in cancer-related bioassays. Over many millions of years of evolution, marine animals have evolved molecules with high binding affinities toward intracellular targets. The opportunity to apply these “evolutionarily significant molecules” within a mechanism-based drug discovery program is thus a rational approach to targeted drug discovery.
This Special Issue on “Marine-Derived Biomolecules” in Biomolecules will cover all scopes of bioassay-directed fractionation of extracts, purification, and structure mapping of marine-derived molecules as well as their biological activities. Biomolecules from marine macro-organisms and/or microbes, new assays’ development, metabolomics, and dereplication of compounds will be targeted in this issue.
As a Special Issue Editor, I invite all colleagues who are actively involved in research related to the marine biomolecules to share their latest findings and results with other colleagues working in the same field. I hope that this Special Issue will provide deep insights into the importance of marine-derived biomolecules as a future source for drug discovery. I also hope that this issue will inspire junior scientists to look for the huge biodiversity of the marine environment and its future impact as leading sources for drug discovery and development.
Prof. Dr. Diaa Youssef
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- marine macro-organisms and micro-organisms
- bioassay-directed fractionation of extracts
- development of new assays for targeting biomolecules
- structure determination of small molecules
- bioactivity and drug leads of marine origin
- metabolomics and dereplication of compounds
- biologically active macromolecules