Special Issue "Functional Amyloids"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (15 May 2017).
Interests: amyloid fibril formation and structure; functional amyloids; hydrophobins; protein misfolding; necroptosis
Interests: microbiology; functional amyloid; protein secretion; extracellular matrix
Interests: functional bacterial amyloid; pathological amyloid; mechanisms of fibrillation in vivo and in vitro; structure of oligomers and fibrils
Interests: protein folding; post-translational modification and quality control; functional amyloids; amyloid-based nanomaterials
There is a growing recognition that the cross β amyloid architecture is found widely in nature, formed by the self-assembly of different proteins and associated with multiple and diverse aspects of normal biology in organisms from microbes to mammals. In so-called “functional amyloid” the amyloidogenic proteins provide desirable self-assembly capability and the biologically active form of the protein is retained or generated in the fibrillar form. The amyloid, multimeric version of the protein has properties beyond that of the monomeric component protein. Functional amyloid fibrils have been shown to have roles in bacterial biofilm formation, fungal adhesion and colonisation, melanin sequestration and subcellular localisation of proteins associated with gene regulation. Studies of disease-associated amyloid formation and structure have laid the foundations for investigation of functional amyloids but recent work on the latter is bringing to light some of the differences in the properties of biologically active and pathological amyloids. We hope that this special issue will highlight exciting recent work in this area as well as stimulate new avenues of research into the biological functions of amyloid, the regulation of functional amyloid and the potential application of amyloids as nanomaterials.
Followed by brief mention of different contributions, putting them in context with each other and the overall theme.
A/Prof. Dr. Margaret Sunde
A/Prof. Dr. Matthew Chapman
Prof. Dr. Daniel Otzen
Prof. Dr. Sarah Perrett
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
mechanisms of fibrillation