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Diversity of Amyloid Motifs in NLR Signaling in Fungi

Institute of Chemistry and Biology of Membranes and Nanoobjects, UMR 5248 CBMN-CNRS Université de Bordeaux, Allée Geoffroy Saint-Hillaire, 33600 Pessac, France
Non-Self Recognition in Fungi, Institut de Biochimie et de Génétique Cellulaire, UMR 5095 CNRS Université de Bordeaux, 1 rue Camille Saint Saëns, 33077 Bordeaux CEDEX, France
Author to whom correspondence should be addressed.
Academic Editors: Margaret Sunde, Matthew Chapman, Daniel Otzen and Sarah Perrett
Biomolecules 2017, 7(2), 38;
Received: 2 March 2017 / Revised: 10 April 2017 / Accepted: 10 April 2017 / Published: 13 April 2017
(This article belongs to the Special Issue Functional Amyloids)
Amyloid folds not only represent the underlying cause of a large class of human diseases but also display a variety of functional roles both in prokaryote and eukaryote organisms. Among these roles is a recently-described activity in signal transduction cascades functioning in host defense and programmed cell death and involving Nod-like receptors (NLRs). In different fungal species, prion amyloid folds convey activation signals from a receptor protein to an effector domain by an amyloid templating and propagation mechanism. The discovery of these amyloid signaling motifs derives from the study of [Het-s], a fungal prion of the species Podospora anserina. These signaling pathways are typically composed of two basic components encoded by adjacent genes, the NLR receptor bearing an amyloid motif at the N-terminal end and a cell death execution protein with a HeLo pore-forming domain bearing a C-terminal amyloid motif. Activation of the NLR receptor allows for amyloid folding of the N-terminal amyloid motifs which then template trans-conformation of the homologous motif in the cell death execution protein. A variety of such motifs, which differ by their sequence signature, have been described in fungi. Among them, the PP-motif bears resemblance with the RHIM amyloid motif involved in the necroptosis pathway in mammals suggesting an evolutionary conservation of amyloid signaling from fungi to mammals. View Full-Text
Keywords: amyloid; prion; programmed cell death; NLR; filamentous fungi amyloid; prion; programmed cell death; NLR; filamentous fungi
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Loquet, A.; Saupe, S.J. Diversity of Amyloid Motifs in NLR Signaling in Fungi. Biomolecules 2017, 7, 38.

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