Cytokines and Cancer

Dear Colleagues,

Cancer is characterized by an abnormal and malignant growth of cells. There are more than 100 types of cancer, and it is the second most common cause of death worldwide, with an estimated 18.1 million new cases of cancer (17 million excluding non-melanoma skin cancer) and 9.6 million deaths from cancer (9.5 million excluding non-melanoma skin cancer) worldwide in 2018 (WHO Global Cancer Observatory (GLOBOCAN) 2018). Tumor formation and progression is a multifactorial process, known to involve the dysregulation of cell growth, proliferation, and angiogenesis, each dependent on numerous different signaling pathways, with kinases playing a pivotal role.

Cytokines are increasingly secreted in response to inflammation, and they have been proposed to be involved in cancer development and progression. Cytokines act as messengers in the cross-talking between cancer cells and tumor-infiltrating immune cells. In addition, cancer cells can respond to host-derived cytokines that promote growth, attenuate apoptosis, and facilitate invasion and metastasis.

This Special Issue shall cover results of studies using animal or cell culture models to investigate the effects of cytokines in cancer, applying molecular biological, biochemical, and cell biological methods. This issue will also publish reports on patients, providing novel mechanistic insights of biomarkers in cancer. In addition, reviews on the current status of cancer biomarkers will be published.

Prof. Dr. Daniela Grimm
Guest Editor

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