To Go Where Nature Leads: Focus on Palmitoylethanolamide and Related ALIAmides As Innovative Approach to Neuroinflammatory and Pain-Related Disease States in Honor of Doctor Francesco Della Valle
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: closed (10 December 2022) | Viewed by 46903
Special Issue Editors
Interests: physiopatology of ischemia and reperfusion (myocardium, intestine, brain); physiopathology of Spinal Cord Injury; physiophatology of Alzheimer and Parkinson Diseases; physiopathology of acute and chronic infiammatory processes in: rheumatoid arthritis, pulmonary fibrosis, pleurisy, colitis; neuroinflammatory and neurodegenerative diseases; endocannabinoids and natural substances
Interests: veterinary pharmacology and toxicology; preclinical and clinical studies of inflammatory and neuroinflamma-tory diseases; endocannabinoids and natural substances, as antioxidant and anti-inflammatory; to improve an-imal health and welfare
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Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue entitled “To go where nature leads: focus on Palmitoylethanolamide and related ALIAmides as innovative approach to neuroinflammatory and pain-related disease states in honor of Doctor Francesco della Valle”. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator and the parent molecule of ALIAmides (i.e., Autacoid Local Injury Antagonist amides). As with other naturally occurring ALIAmides and related endocannabinoids, PEA is naturally synthesized “on demand” in response to actual or potential injuries and serves as an early stop signal to counteract inflammation. Its action depends on multiple molecular targets belonging to the endocannabinoidome. In the last few decades, a growing body of evidence has shown that the regulation of non-neuronal cells—and, therefore, the control of neuroinflammation—depends, at least in part, on the local synthesis of PEA and related endocannabinoids. This mechanism plays important roles in protection against human and animal chronic disorders, ranging from Alzheimer’s disease to enteropathies and from neuropathic pain to allergic dermatitis and itch, to name just a few. Since local and circulating levels of PEA have been repeatedly shown to severely decrease in several conditions, one might envision that the body’s own PEA production is not always fully sufficient. The use of PEA and related ALIAmides, as well as the manipulation of their endogenous levels ,may thus serve as plausible “according-to-Nature” strategies in the management of chronic neuroinflammatory conditions. This Special Issue aims to bring together cutting-edge articles on PEA and related ALIAmides in different in vitro or in vivo disease models and clinical settings in areas of neuroinflammatory and pain-related disorders. We hope this Special Issue can provide a platform for both researchers and practitioners to exchange the latest results on this challenging biopharmaceutics field. We invite you to contribute original research, review articles, or short communications, and we look forward to receiving your contributions.
Prof. Dr. Salvatore Cuzzocrea
Dr. Rosalia Crupi
Guest Editors
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Keywords
- palmitoylethanolamide
- ALIAmides
- neuroinflammation
- pain
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