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Nutrition and Diet for Pain Prevention and Treatment

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (15 February 2025) | Viewed by 1041

Special Issue Editors


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Guest Editor
Department of Clinical and Experimental Medicine, University of Messina, 98166 Messina, Italy
Interests: chronic pain; neuroscience (preclinical/clinical); neuroimmunoinflammation; pain BioPsicoSocialEconomic impact; long COVID syndrome; interdisciplinarity; metadisciplinarity; disease awareness

Special Issue Information

Dear Colleagues,

Advances in scientific research have allowed us to acquire, with increasing certainty, that chronic pain is a disease in itself and that, equally, it is difficult to treat and manage and generates a biological, psychological, social, and economic impact both for the person and for society as a whole. Nevertheless, the need to ensure adequate recovery of pain-induced disability remains unmet

Even today, the therapeutic successes obtained with an exclusively biomedical approach are unsatisfactory and suggest the need to adopt a paradigm shift towards a strategy based on a more holistic approach, hence the emerging interest in the relationship between pain and lifestyle.

Behavioral lifestyle factors (physical activity, stress, sleep disturbances, and an unhealthy diet) are increasingly recognized as crucial factors for the triggering and chronicization of chronic pain.

In 2020, the IASP, based on a large body of evidence indicating the significant effect of nutrition-based interventions on pain reduction, recognized that the relationship between nutrition and chronic pain is important, complex and bidirectional and that optimizing dietary intake in pain management strategies is equally important.

The relationship between nutrition and chronic pain is not yet fully understood, but we can say that it is complex and may involve many underlying (shared) mechanisms, such as oxidative stress, inflammation, and glucose metabolism. Understanding these mechanisms can potentially increase the effectiveness of nutritional assessments and treatments in managing chronic pain: this is also why modern pain management should be multifaceted and include an interdisciplinary approach.

However, nutrition has traditionally been underrepresented in the evidence-based biopsychosocial and lifestyle approach for multimodal and personalized pain management. Instead, healthcare professionals should be aware of all the components involved in pain management, including nutrition, and be able to identify nutrition-related risk factors associated with chronic pain and provide basic nutrition-based treatment strategies. Finally, they should know if, when, and how to refer to a dietician when necessary.

Therefore, pain management requires a comprehensive, interdisciplinary approach that includes nutrition as it is the main modifiable lifestyle factor for chronic non-communicable diseases, including chronic pain.

Based on the above, it is with great pleasure that I invite you to submit contributions to this Special Issue entitled “Diet and Nutrition for Pain Prevention and Treatment”.

The purpose of this Special Issue is:

  1. Summarize the existing evidence on the correlation between nutrition and chronic pain (pain “”disease”, ICD 11th Ed);
  2. Highlight the potential underlying mechanisms that explain the interaction between nutrition and chronic pain and provide targets for mechanism-oriented therapy;
  3. Analytically describe the preclinical and clinical efficacy of both the prevention and management of chronic pain (documented and prospective) of active ingredients present in food;
  4. Present clinical studies aimed at demonstrating a pain-relieving effect resulting from dietary changes represent the bidirectional interaction between nutrition and chronic pain.

Dr. Maurizio Evangelista
Dr. Rosalia Crupi
Guest Editors

Manuscript Submission Information

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Keywords

  • chronic pain
  • ICD-11
  • diet interventions
  • lifestyle
  • nutrients
  • pathogenetic mechanisms
  • neuroimmunoinflammation
  • comorbidities
  • disease awareness
  • interdisciplinarity
  • chronic non specific low back pain

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Published Papers (1 paper)

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Research

17 pages, 1901 KB  
Article
Neuroprotective Potential of Acmella oleracea Aerial Parts and Root Extracts: The Role of Phenols and Alkylamides Against Neuropathic Pain
by Valentina Ferrara, Beatrice Zonfrillo, Maria Bellumori, Marzia Innocenti, Laura Micheli, Valentina Maggini, Daniel Venturi, Eugenia Gallo, Patrizia Bogani, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Nadia Mulinacci and Fabio Firenzuoli
Nutrients 2025, 17(16), 2588; https://doi.org/10.3390/nu17162588 - 8 Aug 2025
Viewed by 659
Abstract
Background: Chemotherapy-induced neuropathic pain is a major side effect of antineoplastic treatment. This study investigated the neuroprotective potential of Acmella oleracea L. extracts containing the N-alkylamide spilanthol, phenolic acids, and glycosylated flavonoids. Methods: Hydroalcoholic extracts of aerial parts (AP) and roots [...] Read more.
Background: Chemotherapy-induced neuropathic pain is a major side effect of antineoplastic treatment. This study investigated the neuroprotective potential of Acmella oleracea L. extracts containing the N-alkylamide spilanthol, phenolic acids, and glycosylated flavonoids. Methods: Hydroalcoholic extracts of aerial parts (AP) and roots (R) of in vitro seedlings were quali-quantitatively characterized by HPLC-DAD-MS and by 1H-NMR. Different concentrations (15–150 µg/mL) of AP and R were tested in SH-SY5Y cells differentiated into neurons exposed to oxaliplatin (10 µM), assessing cell viability (MTT), cytotoxicity (LDH), SOD activity, and expression of ATF-3, Ire1α, and Nf-H genes. To evaluate the impact on neuropathic pain, CD-1 mice were treated intraperitoneally with oxaliplatin (2.4 mg/kg), the effect of AP and R extracts (200–1200 mg/kg) were measured by the cold plate test. Results: AP extract was rich in phenols and alkylamides, whereas R extract showed higher phenolic levels but lower alkylamides content. Both extracts significantly reduced mortality and cytotoxicity and counteracted oxidative imbalance by enhancing SOD activity. Gene expression analysis confirmed their neuroprotective effects. In vivo, oxaliplatin induced a 50% reduction in pain threshold, while acute treatment with AP and R extracts dose-dependently alleviated neuropathic pain. Despite the lower spilanthol content in R extract, its efficacy was comparable to AP, suggesting an important role of phenolic compounds. Conclusions: Extracts from both aerial parts and roots of A. oleracea show promise in alleviating chemotherapy-induced neuropathy through mechanisms not solely related to spilanthol. Further studies to elucidate the contribution of phenolic components are desirable. Full article
(This article belongs to the Special Issue Nutrition and Diet for Pain Prevention and Treatment)
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