PPARs as Key Regulators in Different Diseases

Dear Colleagues,

It is well-established that sedentary living and high-fat food consumption are the main causes of obesity in developed countries. The epidemic of obesity is associated with increased rates of diabetes, hypertension, heart diseases, and many types of cancer and neurodegenerative diseases, resulting in a chronically sick population. In this context, there is no doubt that peroxisome proliferator-activated receptors (PPARs) α, β/δ, and γ play key roles as modulators of lipid homeostasis, in addition to having effects on a variety of cell signals involved in cellular differentiation and development, inflammation, homeostasis, tumorigenesis, etc. If, on the one hand, this makes PPARs and their ligands appealing for their therapeutic potential, on the other hand, their “pluripotent functionality” is associated with a negative perception of PPAR targeting because of insidious side effects that result from this feature. This Special Issue sheds light on new perspectives on PPARs targeting, in terms of both metabolic diseases and other pathologies, with special attention to the structural aspects governing PPARs functions. Alternatively, we would like to invite review articles that address the above-mentioned issues either from a structural or a biological perspective. Any original research papers contributing significantly to advancing our understanding of molecular mechanisms underlying PPARs functions by presenting innovative interpretations are highly welcome.

We look forward to reading your contributions.

Dr. Roberta Montanari
Dr. Davide Capelli
Guest Editors

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