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For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors
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Function, Regulation and Biological Roles of PI3Kγ Variants

1
Department of Pharmacology & Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tübingen, Wilhelmstrasse 56, 72074 Tübingen, Germany
2
Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tübingen, Wilhelmstrasse 56, 72074 Tübingen, Germany
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(9), 427; https://doi.org/10.3390/biom9090427
Received: 23 July 2019 / Revised: 14 August 2019 / Accepted: 15 August 2019 / Published: 30 August 2019
(This article belongs to the Special Issue Phosphoinositide 3-kinase, a Field in Transition)
Phosphatidylinositide 3-kinase (PI3K) γ is the only class IB PI3K member playing significant roles in the G-protein-dependent regulation of cell signaling in health and disease. Originally found in the immune system, increasing evidence suggest a wide array of functions in the whole organism. PI3Kγ occur as two different heterodimeric variants: PI3Kγ (p87) and PI3Kγ (p101), which share the same p110γ catalytic subunit but differ in their associated non-catalytic subunit. Here we concentrate on specific PI3Kγ features including its regulation and biological functions. In particular, the roles of its non-catalytic subunits serving as the main regulators determining specificity of class IB PI3Kγ enzymes are highlighted. View Full-Text
Keywords: PI3K (phosphatidylinositide 3-kinase); class I PI3-kinases; p110γ; p87 (p84); G-proteins; Gβγ; Ras PI3K (phosphatidylinositide 3-kinase); class I PI3-kinases; p110γ; p87 (p84); G-proteins; Gβγ; Ras
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MDPI and ACS Style

Nürnberg, B.; Beer-Hammer, S. Function, Regulation and Biological Roles of PI3Kγ Variants. Biomolecules 2019, 9, 427. https://doi.org/10.3390/biom9090427

AMA Style

Nürnberg B, Beer-Hammer S. Function, Regulation and Biological Roles of PI3Kγ Variants. Biomolecules. 2019; 9(9):427. https://doi.org/10.3390/biom9090427

Chicago/Turabian Style

Nürnberg, Bernd; Beer-Hammer, Sandra. 2019. "Function, Regulation and Biological Roles of PI3Kγ Variants" Biomolecules 9, no. 9: 427. https://doi.org/10.3390/biom9090427

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