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Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, 10126 Turin, Italy
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Biomolecules 2019, 9(3), 104; https://doi.org/10.3390/biom9030104
Received: 30 January 2019 / Revised: 1 March 2019 / Accepted: 11 March 2019 / Published: 15 March 2019
(This article belongs to the Special Issue Phosphoinositide 3-kinase, a Field in Transition)
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Abstract

Phosphorylation of inositol phospholipids by the family of phosphoinositide 3-kinases (PI3Ks) is crucial in controlling membrane lipid composition and regulating a wide range of intracellular processes, which include signal transduction and vesicular trafficking. In spite of the extensive knowledge on class I PI3Ks, recent advances in the study of the three class II PI3Ks (PIK3C2A, PIK3C2B and PIK3C2G) reveal their distinct and non-overlapping cellular roles and localizations. By finely tuning membrane lipid composition in time and space among different cellular compartments, this class of enzymes controls many cellular processes, such as proliferation, survival and migration. This review focuses on the recent developments regarding the coordination of membrane trafficking and intracellular signaling of class II PI3Ks through the confined phosphorylation of inositol phospholipids. View Full-Text
Keywords: PIK3C2A; PIK3C2B; PIK3C2G; PI3K-C2α; PI3K-C2β; PI3K-C2γ; PI3K68D; piki-1; membrane trafficking; signal transduction PIK3C2A; PIK3C2B; PIK3C2G; PI3K-C2α; PI3K-C2β; PI3K-C2γ; PI3K68D; piki-1; membrane trafficking; signal transduction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Margaria, J.P.; Ratto, E.; Gozzelino, L.; Li, H.; Hirsch, E. Class II PI3Ks at the Intersection between Signal Transduction and Membrane Trafficking. Biomolecules 2019, 9, 104.

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