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Function, Regulation and Biological Roles of PI3Kγ Variants
Open AccessFeature PaperReview

The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

by Hyeyoun Chang 1,2,3, Zhenying Cai 1,2 and Thomas M. Roberts 1,2,*
1
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
2
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA
3
KIST-DFCI On-Site Lab, Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(11), 713; https://doi.org/10.3390/biom9110713
Received: 28 September 2019 / Revised: 1 November 2019 / Accepted: 4 November 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Phosphoinositide 3-kinase, a Field in Transition)
In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these mechanisms suggest possible therapeutic approaches for patients with PTEN-null tumors. View Full-Text
Keywords: PI3K; PTEN; cancer PI3K; PTEN; cancer
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Chang, H.; Cai, Z.; Roberts, T.M. The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities. Biomolecules 2019, 9, 713.

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