10th Anniversary of Biomedicines—Advances in Endothelial Dysfunction
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 53886
Special Issue Editors
Interests: endothelial dysfunction; obesity; insulin resistance; diabetic nephropathy; metabolic syndrome; adipokines
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The year 2023 marks the 10th anniversary of Biomedicines, a peer-reviewed open access journal in the biomedical field. Thus far, Biomedicines has published more than 2700 papers from more than 17,000 authors. We appreciate each author, reviewer, and academic editor whose support has brought us to where we are today. To celebrate this significant milestone, we aim to publish a Special Issue entitled “10th Anniversary of Biomedicines—Advances in Endothelial Dysfunction".
Endothelial dysfunction is an early marker of atherosclerosis. Under normal conditions, vascular endothelium maintains blood vessels and keeps them in good shape though synthesis and release of several vasodilatory, anti-inflammatory, and antithombotic substances. Principal among these substances is nitric oxide (NO), which plays a central role in the maintenance of vascular homeostasis. When endothelial dysfunction is induced by pathological stresses, such as hyperlipidemia, hypertension, and hyperglycemia, among others, NO production is impaired and the protective effect of endothelium is disrupted, with consequent vasoconstriction and “activation” of endothelial cells that trigger a cascade of events, resulting in the formation of the atherosclerotic lesion.
Changes in adipose tissue related to obesity result in derangement in the main vascular homeostatic mechanisms, the NO pathway, and the endothelin-1 (ET-1) system, thereby leading to a vasoconstrictor and proatherogenic profile. Derangement of insulin signaling seems to play a central role in the pathophysiology of vascular dysfunction associated with obesity and metabolic syndrome; moreover, the vascular alterations associated with insulin resistance and obesity do not seem to be limited to the endothelium, but also involve other layers of the vessel wall, such as vascular smooth muscle and adventitial/perivascular fat. Perivascular adipose tissue (PVAT) is a potential source of the mediators that lead to obesity-related vascular damage, and conformational changes in perivascular fat have been shown to associate with a loss of anticontractile properties, likely due to inflammatory, vasoconstrictor, and oxidative mechanisms.
For this Special Issue, we are seeking research articles that will improve our knowledge on these topics. Both original research and review articles are welcome.
Prof. Dr. Manfredi Tesauro
Prof. Dr. Carmine Cardillo
Guest Editors
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Keywords
- endothelial dysfunction
- atherosclerosis
- nitric oxide (NO)
- hyperlipidemia
- hypertension
- hyperglycemia
- vasodilation
- perivascular adipose tissue (PVAT)
- insulin resistance
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Related Special Issue
- Biomedicines: 10th Anniversary in Biomedicines (46 articles)