Vascular Function in Chronic Non-communicable Diseases 2.0

Dear Colleagues,

Chronic diseases, in particular non-communicable diseases (NCDs) (like diabetes mellitus, cardiovascular diseases, obesity, cancer, and chronic kidney disease) are one of the major causes of mortality and morbidity worldwide. Currently, the number of people affected by chronic NCDs is much higher than in the past. This data is related to the increase in life expectancy and it is especially valid for countries with a high rate of elderly people. Chronic NCDs, in developed countries, weigh heavily on health expenditure. Dysfunction of endothelium and in the vascular system play a pivotal role in the chronic NCDs pathophysiology. This vascular impairment is, in turn, worsened by an increased production of ROS and in an enhanced release of pro-inflammatory cytokines. Oxidative stress and low-grade chronic inflammatory status are peculiar features of chronic NCDs. Therapeutic strategies useful for counteract vascular involvement and the progression of chronic NCDs include moderate exercise, healthy eating habits and the use of drugs exerting an endothelium-protective action. We welcome the submission of original research articles and review articles on signaling mechanisms, novel therapeutic approaches and clinical observations.

Dr. Annalisa Noce
Dr. Manfredi Tesauro
Guest Editors

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