MicroRNA in Solid Tumor and Hematological Diseases 3.0

Dear Colleagues,

MicroRNAs (miRNAs), short non-coding RNA, are involved in physiologic and pathologic processes. They are critically involved in a wide number of processes, such as differentiation, development, inflammation, immune response, and cancer. MiRNAs play a key role in cancer pathogenesis by inhibiting gene expression at the post-transcriptional level. Moreover, miRNAs are differentially expressed in tumors compared to normal human tissues, and they can be divided into oncomiRNAs and tumor suppressor miRNAs, although some miRNAs can play both roles depending on the cellular context. As a potential therapeutic approach for cancer, extensive studies have demonstrated how to deregulate the small non-coding transcriptome, whether down-regulating the expression of oncogenic miRNAs or overexpressing tumor-suppressive miRNAs. Therefore, accurate analysis of miRNAs expression from cancer patients might be a useful tool to develop personalized medicine in the future.

This Special Issue will focus on the role of miRNAs in controlling pivotal biological mechanisms that lead to oncogenic transformation and tumor formation, growth, and dissemination, as well as their diagnostic and prognostic significance in different cancer subtypes. Original research manuscripts and comprehensive reviews are both welcome for this call.

Dr. Francesca Lovat
Guest Editor

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• microRNAs
• solid tumor
• hematologic malignancies
• cellular pathway analysis
• biomarkers
• cancer genetics
• gene expression
• mouse models