Special Issue "Cytochrome P450 (CYP) in Health and Disease"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 670

Special Issue Editor

Prof. Dr. Grishanova Alevtina
E-Mail Website
Guest Editor
Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Timakova Str. 2/12, 630117 Novosibirsk, Russia
Interests: cytochrome P450; drug metabolism; regulation of gene expression; signal transduction; Ah receptor; genetic polymorphism; oncology; age-related diseases; multidrug resistance

Special Issue Information

Dear Colleagues,

Human cytochrome P450 enzymes play a crucial role in various biological processes and human diseases. Many P450s metabolize drugs used to treat human diseases. Aside from this prominent function, other P450s are necessary for the synthesis of endogenous compounds essential for human physiology. On some occasions, alterations of specific P450s affect the biological processes that they mediate and lead to disease. P450 substrates are exogenous chemicals with potential pathogenic properties. Clinically important P450s are enzymes that act on major endogenous substrates and in many cases control their levels. Therefore, a change in the activity of these P450s often causes severe human diseases. In addition, to date, it remains a challenge to elucidate the role of P450s in the development of chronic diseases. Genetic polymorphism of P450 enzymes and nongenetic factors affecting the expression and activity of these proteins have substantial biological and pathological consequences.

Original manuscripts and reviews dealing with all aspects of the cytochrome P450 superfamily in health and disease are invited to this Special Issue for peer review, to be considered for publication.

Prof. Dr. Grishanova Alevtina
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cytochrome P450 enzymes
  • endogenous substances
  • xenobiotics
  • genetic variants
  • metabolic diseases
  • acute and chronic diseases

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Review
Xenobiotic-Metabolizing Enzymes in Trematodes
Biomedicines 2022, 10(12), 3039; https://doi.org/10.3390/biomedicines10123039 - 24 Nov 2022
Viewed by 114
Abstract
Trematode infections occur worldwide causing considerable deterioration of human health and placing a substantial financial burden on the livestock industry. The hundreds of millions of people afflicted with trematode infections rely entirely on only two drugs (praziquantel and triclabendazole) for treatment. An understanding [...] Read more.
Trematode infections occur worldwide causing considerable deterioration of human health and placing a substantial financial burden on the livestock industry. The hundreds of millions of people afflicted with trematode infections rely entirely on only two drugs (praziquantel and triclabendazole) for treatment. An understanding of anthelmintic biotransformation pathways in parasites should clarify factors that can modulate therapeutic potency of anthelmintics currently in use and may lead to the discovery of synergistic compounds for combination treatments. Despite the pronounced epidemiological significance of trematodes, there is still no adequate understanding of the functionality of their metabolic systems, including xenobiotic-metabolizing enzymes. The review is focused on the structure and functional significance of the xenobiotic-metabolizing system in trematodes. Knowledge in this field can solve practical problems related to the search for new targets for antiparasitic therapy based on a focused action on certain elements of the parasite’s metabolic system. Knowledge of the functionality of this system is required to understand the adaptation of the biochemical processes of parasites residing in the host and mechanisms of drug resistance development, as well as to select a promising molecular target for the discovery and development of new anthelmintic drugs. Full article
(This article belongs to the Special Issue Cytochrome P450 (CYP) in Health and Disease)
Show Figures

Figure 1

Review
The Role of CYP3A in Health and Disease
Biomedicines 2022, 10(11), 2686; https://doi.org/10.3390/biomedicines10112686 - 24 Oct 2022
Viewed by 265
Abstract
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous compounds and diverse xenobiotics (including drugs); almost the [...] Read more.
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous compounds and diverse xenobiotics (including drugs); almost the only common characteristic of these compounds is lipophilicity and a relatively large molecular weight. CYP3A enzymes are widely expressed in human organs and tissues, and consequences of these enzymes’ activities play a major role both in normal regulation of physiological levels of endogenous compounds and in various pathological conditions. This review addresses these aspects of regulation of CYP3A enzymes under physiological conditions and their involvement in the initiation and progression of diseases. Full article
(This article belongs to the Special Issue Cytochrome P450 (CYP) in Health and Disease)
Show Figures

Figure 1

Back to TopTop