Cellular Mechanisms of Physical Stimulation

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 3982

Special Issue Editor


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Guest Editor
Department of Medical Biotechnology (BK21 Plus team), Dongguk University, Goyang-si 10326, Gyeonggi-do, Republic of Korea
Interests: tissue engineering; biomaterials; adult stem cell; differentiation; bioreactor therapic device (electromagnetic filed, ultrasound, mechanical stimulator, LED); anti-aging; pigmentation

Special Issue Information

Dear Colleagues,

Many investigators have studied various stem-cell therapy techniques for diseases that are difficult to treat with drugs. Therefore, many in vitro and pre-clinical studies as well as clinical studies are under way to clarify their efficiency and regenerative effects.

Various bioreactors and devices have been developed to improve cell differentiation and activity,

such as the electromagnetic field, electrical stimulation, ultrasound, mechanical stimulation, the light-emitting diode (LED), and low-level laser therapy (LLLT). Furthermore, these devices have been developed into physical therapy devices and have been applied in vivo as well as in vitro.

Therefore, for this Special Issue, entitled ”Cellular Mechanisms of Physical Stimulation”, we would like to invite relevant studies on the mechanisms of promoting cell differentiation or activity and maximizing the therapeutic efficiency of cells injected into the in vivo environment through combining physical stimulation techniques and various cell therapy technologies.

Potential topics include, but are not limited to, the following:

-Cellular mechanisms of physical stimulation for activation or differentiation;

-Cellular mechanisms of physical stimulation for wound healing;

-Immune cell mechanisms of physical stimulation for immune disease or cancer therapy;

-Synergistic effects of cell and physical stimulation for regeneration.

We hope you find this an exciting and unique opportunity to contribute to this research area by publishing in Biomedicines.

Prof. Dr. Young-Kwon Seo
Guest Editor

Manuscript Submission Information

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Published Papers (1 paper)

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Research

16 pages, 4641 KiB  
Article
Extremely Low-Frequency Electromagnetic Fields Increase Cytokines in Human Hair Follicles through Wnt/β-Catenin Signaling
by Ju-Hye Choi, Yu-Mi Kim, Hee-Jung Park, Myeong-Hyun Nam and Young-Kwon Seo
Biomedicines 2022, 10(4), 924; https://doi.org/10.3390/biomedicines10040924 - 18 Apr 2022
Cited by 2 | Viewed by 3455
Abstract
Hair loss is a chronic disorder that affects many people; however, a complete treatment has not yet been developed. Therefore, new therapeutic agents for preventing hair loss must be developed, and electromagnetic field (EMF) therapy has been proven to be a promising medical [...] Read more.
Hair loss is a chronic disorder that affects many people; however, a complete treatment has not yet been developed. Therefore, new therapeutic agents for preventing hair loss must be developed, and electromagnetic field (EMF) therapy has been proven to be a promising medical treatment in various fields, including hair loss treatment. This study evaluated the effect of extremely low-frequency electromagnetic field (ELF-EMF) intensity and exposure time by analyzing the expression of cytokines and anagen-related molecules, which influence hair activation and growth, in hair bulb spheroid (HBS) and hair follicle (HF) organ cultures. ELF-EMFs did not induce toxicity in the HBSs, as verified via the lactate dehydrogenase (LDH) assay. Moreover, an ELF-EMF intensity of 5–20 G promoted the expression of ALP, versican, β-catenin, and several cytokines (VEGF, PDGF, FGF-10, and ET-1) in HBSs. Immunohistochemical staining showed that ELF-EMF at an intensity of 5–20 G upregulated ALP and β-catenin and decreased TUNEL staining in HBS. Moreover, HFs exposed to ELF-EMF for 60 min exhibited an increase in hair length and a 1.5-fold increase in IL-4, ICAM-1, ALP, and versican mRNA expression compared to the control. Immunohistochemical staining indicated that 60 min of ELF-EMF can increase the expression of ALP and β-catenin and decreases TUNEL staining in organ cultures. Collectively, our results demonstrated that ELF-EMF exposure at a 10 G intensity for 60 min promoted hair shaft growth in HFs due to the effect of cytokines and adhesion molecules via the Wnt/β-catenin pathway. Therefore, ELF-EMF is a promising treatment for hair loss. Full article
(This article belongs to the Special Issue Cellular Mechanisms of Physical Stimulation)
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