New Challenges in Liver Diseases: From Molecular Pathogenesis to Therapeutic Approaches
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 24
Special Issue Editor
Interests: liver fibrosis; cirrhosis; non-alcoholic fatty liver disease (NAFLD); hepatitis B virus (HBV) pathogenesis; acute-on-chronic liver failure (ACLF); immune regulation; therapeutic strategies for chronic liver diseases.
Special Issue Information
Dear Colleagues,
Liver diseases represent a global health crisis, encompassing a broad spectrum of disorders, from viral hepatitis and metabolic dysfunction-associated steatotic liver disease (MASLD) to hepatocellular carcinoma (HCC). Despite advances in diagnostics and therapeutics, challenges persist in understanding molecular mechanisms, achieving functional cures for chronic infections (e.g., HBV), developing clinical treatments for acute-on-chronic liver failure (ACLF), and addressing the rising burden of non-alcoholic steatohepatitis (NASH).
This Special Issue will showcase cutting-edge research on the following topics:
- Molecular Pathogenesis: Host–virus interactions, epigenetic regulation, metabolic dysregulation, and immune dysfunctions in liver diseases;
- Therapeutic Innovations: Novel targets (e.g., cccDNA, RNA interference), combination therapies, and precision medicine approaches;
- Translational Advances: Non-invasive biomarkers, regenerative medicine, and gut–liver axis modulation;
- Global Health Priorities: Elimination strategies for viral hepatitis;
By bridging basic science, clinical research, and innovation, this Special Issue will accelerate the progress toward curing liver diseases and improving patient outcomes worldwide.
Prof. Dr. Yefu Wang
Guest Editor
Manuscript Submission Information
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Keywords
- liver fibrosis
- NAFLD/NASH
- ACLF
- HBV cure
- immunotherapy
- precision medicine
- metabolic liver diseases
- gut–liver axis
- regenerative medicine
- biomarkers
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