Male Reproductive Medicine: From Basic to Clinical Research

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 166

Special Issue Editor


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Guest Editor
1. Institute of Reproduction Health Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2. Shenzhen Huazhong University of Science and Technology Research Institute, Shenzhen 518109, China
Interests: spermatogenesis; epididymal sperm maturation; Oogenesis; fertilization

Special Issue Information

Dear Colleagues,

Over the past few decades, significant advances have been made in understanding the complex biological, genetic, and environmental factors that influence male reproductive function. However, challenges such as declining sperm quality, increasing rates of male infertility, and the impact of lifestyle and environmental factors on reproductive health continue to demand innovative solutions and a deeper understanding of the underlying mechanisms.

This Special Issue, titled "Male Reproductive Medicine: From Basic to Clinical Research," aims to bridge the gap between foundational scientific discoveries and their translation into clinical practice. By bringing together cutting-edge research from diverse disciplines, this Special Issue seeks to highlight the latest advancements in male reproductive medicine, from molecular and cellular studies to large-scale clinical trials and innovative therapeutic approaches. Topics of interest include, but are not limited to, spermatogenesis, hormonal regulation, genetic and epigenetic influences, environmental toxicology, lifestyle factors, and emerging technologies in diagnostics and treatment.

We invite researchers, clinicians, and experts in the field to share their insights, findings, and perspectives. By fostering interdisciplinary collaboration and knowledge exchange, this Special Issue aspires to advance our understanding of male reproductive health and pave the way for improved diagnostic tools, therapeutic interventions, and patient outcomes. Together, we can address the pressing challenges in male reproductive medicine and contribute to a healthier future for individuals and families worldwide.

Prof. Dr. Donghui Huang
Guest Editor

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Keywords

  • male reproductive function
  • spermatogenesis
  • hormonal regulation
  • genetic and epigenetic influences
  • environmental toxicology
  • male reproductive health

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Published Papers (1 paper)

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Review

20 pages, 833 KiB  
Review
Progress in Investigating the Impact of Obesity on Male Reproductive Function
by Yafei Kang, Peiling Li, Suying Yuan, Sen Fu, Xue Zhang, Jiaxing Zhang, Chenle Dong, Renhui Xiong, Hu Zhao and Donghui Huang
Biomedicines 2025, 13(9), 2054; https://doi.org/10.3390/biomedicines13092054 (registering DOI) - 23 Aug 2025
Abstract
Obesity represents a significant global public health challenge, which not only elevates the risk of mortality but also increases the likelihood of chronic diseases. The ongoing obesity epidemic has led to a growing recognition of the detrimental effects of excessive adipose tissue accumulation [...] Read more.
Obesity represents a significant global public health challenge, which not only elevates the risk of mortality but also increases the likelihood of chronic diseases. The ongoing obesity epidemic has led to a growing recognition of the detrimental effects of excessive adipose tissue accumulation on male reproductive health. Substantial evidence indicates that obesity adversely affects sperm quality, thereby impairing male fertility. Specifically, obesity is associated with compromised spermatogenesis, erectile dysfunction, and detrimental effects on offspring fertility parameters. These effects are mediated through various mechanisms, including alterations in the hypothalamic–pituitary–gonadal axis, inflammation within the reproductive system, localized caloric excess in reproductive tissues, epigenetic modifications, disruptions in gut microbiota, and heightened oxidative stress levels. While the molecular alterations associated with obesity have been extensively documented, the precise mechanisms by which obesity influences male reproductive function remain inadequately understood. This article aimed to review the classification and distribution of adipose tissue in obesity, the impact of obesity on male fertility, and the potential mechanisms through which obesity affects male reproductive health, thereby offering insights into the prevention and treatment of obesity-related male fertility issues. Full article
(This article belongs to the Special Issue Male Reproductive Medicine: From Basic to Clinical Research)
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