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Biomedicines
Special Issues
Applications and Developments of Metal-Based Drugs
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Applications and Developments of Metal-Based Drugs

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Drug Discovery, Development and Delivery".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 237

Special Issue Editor

Dr. Sajal Sen

E-Mail Website
Guest Editor
Department of Biological Engineering, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA
Interests: medicinal inorganic chemistry; immunotherapy agents; neuroimaging; anticancer agents; multimodal probes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of metal-based compounds in medicine has been a practice for thousands of years and continues to progress alongside modern advancements. Metal complexes, such as platinum derivatives for anticancer therapy and gold compounds for treating rheumatoid arthritis, demonstrate their diverse therapeutic potential. Metal complexes possess unique chemical structures and reactivities that can be finely tuned with ligand frameworks and oxidation states, offering advantages over traditional organic drugs. This Special Issue of Biomedicines focuses on the latest innovations in the field. It welcomes contributions related to the design, synthesis and optimization of metal complexes for use as therapeutic and diagnostic tools. The emphasis is on understanding the mechanisms of action, identifying in vivo targets and optimizing delivery methods using carriers such as nanoparticles or liposomes. Furthermore, the Special Issue explores the role of metal complexes in molecular imaging, particularly radiopharmaceuticals for investigating various diseases. By providing a dedicated platform for interdisciplinary research, the Special Issue aims to advance knowledge and promote new strategies in inorganic medicinal chemistry to facilitate the clinical translation of such compounds in the future.

Dr. Sajal Sen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anticancer
  • anti-infectious diseases
  • nuclear medicines
  • immunotherapeutic
  • drug delivery
  • organometallic complexes
  • metal-based drugs
  • metallotherapeutic drugs

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Published Papers (1 paper)

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Review

18 pages, 789 KiB  
Review
Nanotechnology in Osteogenesis and Inflammation Management: Metal–Organic Frameworks, Metal Complexes, and Biomaterials for Bone Restoration
by Bogdan Huzum, Ionut Iulian Lungu, Ovidiu Alexa, Paul Dan Sirbu, Viorel Dan Cionca, Andreia Corciova, Andreea Lungu, Monica Hancianu, Ionela Lacramioara Serban and Oana Cioanca
Biomedicines 2025, 13(7), 1597; https://doi.org/10.3390/biomedicines13071597 - 30 Jun 2025
Abstract
A varied family of polyphenolic chemicals, flavonoids, are becoming more and more important in bone tissue engineering because of their osteogenic, anti-inflammatory, and antioxidant effects. Recent developments incorporating flavonoids into different biomaterial platforms to improve bone regeneration are emphasized in this study. Osteocalcin [...] Read more.
A varied family of polyphenolic chemicals, flavonoids, are becoming more and more important in bone tissue engineering because of their osteogenic, anti-inflammatory, and antioxidant effects. Recent developments incorporating flavonoids into different biomaterial platforms to improve bone regeneration are emphasized in this study. Osteocalcin (OCN) expression was 2.1-fold greater in scaffolds loaded with flavonoids—such as those made of polycaprolactone (PCL)—greatly increasing human mesenchymal stem cell (hMSC) proliferation and mineralization. Comparably, a threefold increase in calcium deposition indicates increased mineralization when hydroxyapatite (HA) was functionalized with flavonoids such as quercetin. These HA scaffolds with flavonoids also showed a 45% decrease in osteoclast activity, therefore promoting balanced bone remodeling. Concurrent with flavonoids like EGCG and quercetin, chitosan-based scaffolds encouraged osteogenic differentiation with increases in osteogenic markers like osteopontin (OPN) and alkaline phosphatase (ALP) expression by up to 82%. These scaffolds also showed 82% bone defect repair after six weeks in vivo, suggesting their promise in rapid bone regeneration. With an increase of up to 32% in the bone volume-to-total volume ratio (BV/TV) and 28% greater bone–implant contact (BIC), flavonoid coatings on titanium implants enhanced osteointegration in implantology. Displaying successful osteogenesis and immunomodulation, the addition of flavonoids into metal–organic frameworks (MOFs) and injectable hydrogels demonstrated a 72% increase in new bone formation in vivo. Though further research is required to confirm long-term clinical effectiveness, these findings show the great promise of flavonoid-functionalized biomaterials in bone regeneration. Full article
(This article belongs to the Special Issue Applications and Developments of Metal-Based Drugs)
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