NASH and Hepatocellular Carcinoma (HCC)—2nd Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 81
Special Issue Editors
Interests: obesity; NASH; hepatocellular carcinoma (HCC)
Special Issues, Collections and Topics in MDPI journals
Interests: gut microbiota; MAFLD; immunemetabolism
Special Issue Information
Dear Colleagues,
Caloric excess and sedentary lifestyles are growing health concerns that have led to a global epidemic of obesity and metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity and metabolic syndrome, is a major cause of liver disease worldwide, and its prevalence is increasing in parallel with obesity and type 2 diabetes. This spectrum of NAFLD ranges from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis, which ultimately leads to hepatocellular carcinoma (HCC), a leading cause of cancer-related deaths worldwide. Liver damage associated with NASH leads to a cycle of cell death, liver regeneration, and fibrosis, during which HCC precursor cells undergo malignant transformation, leading to cancer initiation. Several mechanisms have been proposed to underlie the progression of NASH to cirrhosis, and eventually HCC, including cell death, ER stress, mitochondrial dysfunction, inflammation, and oxidative stress. The mechanisms of progression of NASH, fibrosis, and HCC are far from being understood.
In this Special Issue, we aim to present a series of review and research articles that elucidate the progression in the diagnosis, prevention, and treatment of NASH and HCC, along with the many challenges that still remain. We welcome basic, translational, and clinical studies that deepen our understanding of disease progression from NASH and HCC, as well as those exploring potential new therapies.
Dr. Feng He
Dr. Ruirui Wang
Dr. Xin Yang
Guest Editors
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Keywords
- NAFLD
- NASH
- HCC
- obesity
- inflammation
- immunotherapy
- stress
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Related Special Issue
- NASH and Hepatocellular Carcinoma (HCC) in Biomedicines (5 articles)
