The Mechanism of Enzymatic Action

Dear Colleagues,

The molecular aspects of enzymatic actions are of fundamental scientific interest; they are simply related to protein chemistry and to substrate/product molecules, including, also, all aspects of the chemistry of the reaction, such as solvents, temperature, etc. It could seem an evergreen topic since beginning of disciplines such as biochemistry, organic chemistry, etc. of the last century, and as such a special issue dedicated to it could be considered no more than remembrance of good old times.

However, recent discovery of new environments, inhabited by unknown micro- and macroorganisms, has provided new scientific subjects in terms of fundamental and applied science, in the marine and extreme domains of remote regions of the globe, as the most promising pillars.

Therefore, reviewing and focusing on the mechanisms of enzymatic action seems again appropriate, providing a broadened significance of the terms. In terms of fundamental science, bioprocesses of new enzymes from unknown habitats are characterized by unique aspects based on (i) habitat-related properties (salt tolerance, hyperthermostability, barophilicity, cold adaptivity, etc.) and on (ii) molecular aspects, such as new stereochemistry. In terms of applied science, the title of this Special Issue should be considered under the (bio)technological aspects of enzymatic catalysis, acquiring the widest significance in such a way that chemists, biologists, etc., could contribute to the molecularity of catalysis on the one hand, and engineers and biotechnologists, for product quality and technological aspects of bioprocesses, on the other hand.

In this Special Issue articles or reviews concerning molecular and technological aspects of enzymatic action are expected in order to discuss more recent discoveries in new biocatalysts.

As the Guest Editor, I invite researchers from industry and academia, working with enzymes, to describe recent advances in the field.

Dr. Antonio Trincone
Guest Editor

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• Biocatalysts
• Enzymes
• Bioprocesses
• Applied biology
• Biomolecular and metabolic engineering