Special Issue "Biomolecules in Complex Biological and Biochemical Systems – Selected Papers from ICBB2019"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 June 2020.

Special Issue Editors

Prof. Dr. Anna Kurzyńska-Kokorniak
Website
Guest Editor
Department of Ribonucleoprotein Biochemistry, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Z. Noskowskiego 12/14, 61-704 Poznań, Poland
Interests: Ribonuclease Dicer; RNA-binding proteins; regulatory RNAs; RNA-protein interactions; regulation of activity of Dicer-type ribonucleases; regulation of gene expression
Dr. Antonio Trincone
Website
Guest Editor
Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, Edificio 70, Via Campi Flegrei 34, I-80078 Pozzuoli, Napoli, Italy
Interests: biocatalysis; marine enzymes; marine glycosidases; marine biotechnology; oligosaccharides
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The 2019 International Conference on Biotechnology and Bioengineering (9th ICBB 2019) will be held in Poznan, Poland during 25–28 September 2019. The ICBB2019 is co-organized by the Asia-Pacific Association of Science, Engineering and Technology (APASET), the Institute of Bioorganic Chemistry Polish Academy of Sciences (IBCH PAS), the Adam Mickiewicz University (AMU), and the Chinese Journal of Biologicals (CJB).

The conference has been designed to present an innovative and comprehensive overview of biotechnology and bioengineering, and its focus on major research advances in microbiology, virology, cytology and immunology; biological macromolecules, proteins and nucleic acids; biomaterials, biopolymers and bioenergy; biomedicine, biopharmaceuticals, pharmacology and toxicology; agricultural, food and industrial biotechnology; applications in bioengineering, biomedical engineering and technology; and other related aspects.

More information about the conference can be found at https://www.icbb.ibch.poznan.pl/

Participants of the conference are cordially invited to contribute original research papers or reviews to this Special Issue of Biomolecules. We welcome submissions of previously unpublished original work on all aspects and applications of biomolecules.

Prof. Dr. Anna Kurzyńska-Kokorniak
Dr. Antonio Trincone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nucleic acids and proteins
  • lipids and membrane
  • natural products, bioactivity and biosynthesis
  • biosensors, biomarkers and nanobiotechnology
  • bioinformatics and systems biology
  • 3D structures and 3D cultures
  • disease mechanisms
  • high content/throughput screening

Published Papers (3 papers)

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Research

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Open AccessArticle
The Genoprotective Role of Naringin
Biomolecules 2020, 10(5), 700; https://doi.org/10.3390/biom10050700 - 30 Apr 2020
Abstract
Since ancient times, fruits and edible plants have played a special role in the human diet for enhancing health and maintaining youthfulness. The aim of our work was to determine the interactions between naringin, a natural ingredient of grapefruits, and DNA using an [...] Read more.
Since ancient times, fruits and edible plants have played a special role in the human diet for enhancing health and maintaining youthfulness. The aim of our work was to determine the interactions between naringin, a natural ingredient of grapefruits, and DNA using an electrochemical biosensor. Electrochemical methods allow analyzing the damages occurring in the structure of nucleic acids and their interactions with xenobiotics. Our study showed that the changes in the location of electrochemical signals and their intensity resulted from the structural alterations in DNA. The signal of adenine was affected at lower concentrations of naringin, but the signal of guanine was unaffected in the same condition. The dynamics of changes occurring in the peak height and surface of adenine related to naringin concentration was also significantly lower. The complete binding of all adenine bases present in the tested double-stranded DNA solution was observed at naringin concentrations ranging from 8.5 to 10.0 µM. At larger concentrations, this active compound exerted an oxidizing effect on DNA. However, the critical concentrations of naringin were found to be more than twice as high as the dose absorbable in an average human (4 µM). The results of our work might be helpful in the construction of electrochemical sensors for testing the content of polyphenols and would allow determining their genoprotective functionality. Full article
Open AccessArticle
Monosodium Glutamate (MSG) Renders Alkalinizing Properties and Its Urinary Metabolic Markers of MSG Consumption in Rats
Biomolecules 2019, 9(10), 542; https://doi.org/10.3390/biom9100542 - 27 Sep 2019
Abstract
Monosodium glutamate (MSG) is widely used as a flavor enhancer and its effects on human health are still debated. We aimed to investigate whether MSG can act as alkalinizing agent in murine models and if its metabolites are biomarkers of MSG consumption. For [...] Read more.
Monosodium glutamate (MSG) is widely used as a flavor enhancer and its effects on human health are still debated. We aimed to investigate whether MSG can act as alkalinizing agent in murine models and if its metabolites are biomarkers of MSG consumption. For this purpose, adult male Wistar rats were given water added with 1 g% MSG or three types of control water, including sodium chloride (NaCl) and sodium bicarbonate (NaHCO3). At 14 days, urinary pH, electrolytes, urinary metabolites and ion-exchanger gene expression were determined. The results revealed that MSG-treated rats had significantly more alkaline urine and higher levels of urinary sodium and bicarbonate similar to NaHCO3 controls. These changes correlated with a lower expression of ion-exchanger genes, namely, CAII, NBC1, and AE1, which are involved in bicarbonate kidney reabsorption. The urinary metabolic profiles also revealed similar patterns for the MSG and NaHCO3 groups. In conclusion, MSG exhibits similar properties to NaHCO3, an alkalinizing agent, with regard to inducing alkaline urine, reducing bicarbonate kidney reabsorption, and generating a specific urinary metabolic pattern. We believe that these observations will be useful to further study the MSG effects in humans. Full article
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Review

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Open AccessReview
Recent Advances in Molecular Mechanisms of the NKG2D Pathway in Hepatocellular Carcinoma
Biomolecules 2020, 10(2), 301; https://doi.org/10.3390/biom10020301 - 14 Feb 2020
Cited by 1
Abstract
Hepatocellular carcinoma is a common malignant tumor with high mortality. Its malignant proliferation, invasion, and metastasis are closely related to the cellular immune function of the patients. NKG2D is a key activated and type II membrane protein molecule expressed on the surface of [...] Read more.
Hepatocellular carcinoma is a common malignant tumor with high mortality. Its malignant proliferation, invasion, and metastasis are closely related to the cellular immune function of the patients. NKG2D is a key activated and type II membrane protein molecule expressed on the surface of almost all NK cells. The human NKG2D gene is 270 kb long, located at 12p12.3–p13.1, and contains 10 exons and 9 introns. The three-dimensional structure of the NKG2D monomeric protein contains two alpha-helices, two beta-lamellae, and four disulfide bonds, and its’ signal of activation is transmitted mainly by the adaptor protein (DAP). NKG2D ligands, including MICA, MICB, and ULBPs, can be widely expressed in hepatoma cells. After a combination of NKG2D and DAP10 in the form of homologous two polymers, the YxxM motif in the cytoplasm is phosphorylated and then signaling pathways are also gradually activated, such as PI3K, PLCγ2, JNK-cJunN, and others. Activated NK cells can enhance the sensitivity to hepatoma cells and specifically dissolve by releasing a variety of cytokines (TNF-α and IFN-γ), perforin, and high expression of FasL, CD16, and TRAIL. NK cells may specifically bind to the over-expressed MICA, MICB, and ULBPs of hepatocellular carcinoma cells through the surface activating receptor NKG2D, which can help to accurately identify hepatoma, play a critical role in anti-hepatoma via the pathway of cytotoxic effects, and obviously delay the poor progress of hepatocellular carcinoma. Full article
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