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Bioengineering publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Technologies for Orthopedic Repair and Regeneration

edited by Adriano Braile,

Mariantonia Braile

and Giuseppe Toro

submission deadline 28 Feb 2026 | Viewed by 70 | Submission Open

Keywords: orthopedic regeneration; 3D printing; bioactive materials; mesenchymal stem cells; smart biomaterials; tissue engineering; predictive modeling; immunoengineering; antimicrobial strategies; personalized implants

(This special issue belongs to the Section Regenerative Engineering)

Wearable Sensors and Robotic-Assisted Technologies for Activity Assistance and Gait Rehabilitation

edited by

Chun-Ta Chen

and Xiaoling Hu

submission deadline 28 Feb 2026 | Viewed by 67 | Submission Open

Keywords: wearable sensors; robotic-assisted technology; activity assistance; gait rehabilitation; balance; movement impairment; exoskeleton robot

(This special issue belongs to the Section Biosignal Processing)

Multiscale Mechanics of Biomaterials

edited by Pengfei Dong,

Linxia Gu

and Yi Hua

submission deadline 28 Feb 2026 | Viewed by 66 | Submission Open

Keywords: multiscale mechanics; atomic force microscopy; machine learning; biomaterials; finite element method

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Advances in Soft Matter for Healthcare Applications

edited by

Ahmed Abass

submission deadline 28 Feb 2026 | Viewed by 66 | Submission Open

Keywords: soft matter; healthcare applications; hydrogels; drug delivery systems; flexible electronics; tissue engineering; soft robotics; bio-inspired materials; responsive materials; wearable sensors; biomedical devices; smart materials; thermally active materials; hot water bottles; pain management; biocompatible materials; clinical translation

Mechanobiology in Biomedical Engineering—2nd Edition

edited by Chun-Yuh Huang

submission deadline 28 Feb 2026 | Viewed by 64 | Submission Open

Keywords: mechanobiology; stem cells; tissue engineering; cancer; bone; articular cartilage; intervertebral disk; chondrocytes; tumor microenvironment; organ fibrosis; mechanotransduction; muscle; skin; liver; kidney; heart; blood vessel; brain; nerve; periodontal ligament; tooth; dental tissue; mechanical force; organoids

(This special issue belongs to the Section Biomechanics and Sports Medicine)

Stem Cell Culture and Development of Tissue Engineered Models

edited by

Giuseppe Pettinato

submission deadline 28 Feb 2026 | Viewed by 59 | Submission Open

Keywords: stem cell culture; tissue engineering; organoids; biomaterials; 3D cell culture; regenerative medicine; disease modeling; organ-on-a-chip

(This special issue belongs to the Section Regenerative Engineering)

Biofabrication of Biologically Realistic Constructs: Needs, Challenges, and Opportunities

edited by Nicanor Ilie Moldovan

submission deadline 28 Feb 2026 | Viewed by 51 | Submission Open

Keywords: biofabrication; biological realism; bioprinting; cell– biomaterial interaction; tissue engineering; hybrid constructs; clinical translation; in vitro models

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Artificial Intelligence in Dentistry: Innovations, Applications, and Future Perspectives, 2nd Edition

edited by

Hang Nga Mai

and

Tim Joda

submission deadline 28 Feb 2026 | Viewed by 49 | Submission Open

Keywords: artificial intelligence; big data in dentistry; explainable AI in dental diagnostics; blockchain in dental data security; natural language processing in dental records; robotics in dentistry; smart dental devices; AI in clinical decision support; automation in dentistry; AI-based diagnostic imaging; AI-supported treatment planning

(This special issue belongs to the Section Biosignal Processing)

Big Data and Artificial Intelligence in Trauma Outcome Prediction

edited by Peter Fu Ming Hu, Shiming Yang and William Teeter

submission deadline 28 Feb 2026 | Viewed by 42 | Submission Open

Keywords: trauma triage; emergency medicine; clinical decision support; outcome prediction; precision medicine; artificial intelligence; natural language processing

(This special issue belongs to the Section Biosignal Processing)

Advanced 3D-Printed Biomaterials in Dentistry

edited by Andreas Zenthöfer and Ralf Erber

submission deadline 28 Feb 2026 | Viewed by 40 | Submission Open

Keywords: additive manufacturing; 3D printing; ceramics; polymer-based materials; bone substitutes

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

From 3D/4D Printing to Biofunctional Surfaces and Smart Implant Systems

edited by

Yuhe Yang

submission deadline 28 Feb 2026 | Viewed by 35 | Submission Open

Keywords: 3D/4D printing; biofunctional surfaces; smart implants; additive manufacturing in biomedicine

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Engineering with Nature: Bioengineering Innovations for the Environment and Nature-Based Solutions

edited by

Kristian L. Dubrawski

submission deadline 28 Feb 2026 | Viewed by 34 | Submission Open

Keywords: nature-based solutions; bioengineering; environmental sustainability; bioremediation; ecological engineering

(This special issue belongs to the Section Biochemical Engineering)

Polymeric Biomaterials for Drug Delivery

edited by

Pere Dosta Pons

submission deadline 28 Feb 2026 | Viewed by 27 | Submission Open

Keywords: biomaterials; polymeric nanoparticles; stimuli-responsive systems; biodegradable polymers; drug delivery; gene therapy; targeted delivery; controlled release

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Multimodal AI‑Assisted Bioprinting: From Material Selection to Automated Fabrication

edited by Ewa Stodolak-Zych,

Ryszard Tadeusiewicz

and Kamila Rawojć

submission deadline 28 Feb 2026 | Viewed by 26 | Submission Open

Keywords: 3D bioprinting; artificial intelligence; machine learning; bioink design; tissue engineering; multimodal data; closed-loop fabrication; automated manufacturing

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Bioinformatics for Cardiovascular Disease

edited by João P. Monteiro and Quanyi Zhao

submission deadline 28 Feb 2026 | Viewed by 26 | Submission Open

Keywords: bioinformatics; cardiovascular disease; single-cell RNA-seq; single-cell ATAC-seq; spatial profiling; genomics; machine learning; multi-omics integration; systems biology; cardiac modeling; precision medicine; big data; translational bioinformatics

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

AI-Driven Approaches to Diseases Detection and Diagnosis

edited by Yannis Trakadis and

Antonio Brunetti

submission deadline 28 Feb 2026 | Viewed by 25 | Submission Open

Keywords: AI-driven diagnostics; disease detection; machine learning; deep learning; medical imaging; digital biomarkers; clinical decision support; multi-modal data

(This special issue belongs to the Section Biosignal Processing)

Advances in Novel Remineralizing Materials: Innovations for Sustainable Oral and Biomedical Applications

edited by Robert Hill

submission deadline 28 Feb 2026 | Viewed by 24 | Submission Open

Keywords: dental materials; remineralization; bioactive glass; glass ionomer cements; calcium phosphate cements; nanotechnology; adhesion; sustainable dentistry; clinical performance; biomedical engineering

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Advanced Cryopreservation and Innovative Rewarming Strategies for Cells, Tissues, Organs and Organisms

edited by

Risco Ramon

and

Estefanía Paredes

submission deadline 10 Mar 2026 | Viewed by 3 | Submission Open

Keywords: cryopreservation; vitrification strategies; rewarming technologies; cryoprotective agents; fertility preservation; plant cryobiology; aquatic species conservation; astrobiology and extreme environments

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Machine Learning in Ultrasound Imaging

edited by Laura Brattain, Vivek Singh and Md Mostafa Kamal Sarker

submission deadline 15 Mar 2026 | Viewed by 1 | Submission Open

Keywords: computer-aided diagnosis; medical image analysis; image segmentation; procedural guidance; clinical decision support; elastography; contrast-enhanced ultrasound; point-of-care ultrasound (POCUS); multimodal imaging

(This special issue belongs to the Section Biosignal Processing)

Recent Advances in Genomics Research

edited by Chien-Wei (Masaki) Lin

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3647 | Submission Open

Keywords: genomics data analysis; NGS; AI; machine learning; multi-omics integration; single-cell sequencing; precision medicine

(This special issue belongs to the Section Cellular and Molecular Bioengineering)

Innovative Approaches: Harnessing Virtual Reality for Assessment and Rehabilitation in Stroke and Aging-Related Disorders

edited by Gauthier Everard and

Charles Sebiyo Batcho

submission deadline 31 Mar 2026 | 4 articles | Viewed by 3318 | Submission Open

Keywords: virtual reality; assessment; rehabilitation; stroke; neurorehabilitation; older adults; kinematics; cognition

(This special issue belongs to the Section Biosignal Processing)

Augmented Reality, Virtual Reality and Extended Reality Solutions for Biomedical Applications

edited by

Vera Gramigna

and Arrigo Palumbo

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2341 | Submission Open

Keywords: augmented reality (AR); virtual reality (VR); extended reality (XR); biomedicine; human– robot interaction; technology in healthcare; medical imaging; surgical simulation; surgical navigation; robotic-assisted surgery; rehabilitation technology; neurological disorders’ treatment; pain management; personalized healthcare; artificial intelligence (AI) in medicine; human– computer interaction in healthcare; digital health technologies

(This special issue belongs to the Section Biosignal Processing)

Novel Imaging Techniques in Radiotherapy

edited by

Zijian Deng

and Junwei Shi

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1899 | Submission Open

Keywords: radiotherapy; imaging; tumor localization; treatment assessment; radiation toxicity

(This special issue belongs to the Section Biosignal Processing)

Bioengineering and the Eye—3rd Edition

edited by

Dimitrios Karamichos

submission deadline 31 Mar 2026 | 1 articles | Viewed by 924 | Submission Open

Keywords: stem cell therapies; functional ocular tissue equivalents; biomaterials; 3D bioprinting; tissue engineering

(This special issue belongs to the Section Regenerative Engineering)

Contemporary Trends and Future Perspectives in Orthodontic Treatment

edited by

Simone Parrini

and

Gabriele Rossini

submission deadline 31 Mar 2026 | 1 articles | Viewed by 916 | Submission Open

Keywords: orthodontic biomechanics; clear aligners; digital orthodontics; artificial intelligence; finite element analysis; interdisciplinary treatment; patient experience; long-term stability; innovative appliances; future trends in orthodontics

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Contribution of Bioprocess Engineering to the Achievement of the UN Sustainable Development Goals (SDGs)

edited by

Dirk Holtmann

submission deadline 31 Mar 2026 | 1 articles | Viewed by 849 | Submission Open

Keywords: bioprocess engineering; sustainability; sustainable development goals (SDGs)

(This special issue belongs to the Section Biochemical Engineering)

Nanobiosensors for Age-Related Diseases Diagnosis

edited by

Chaker Tlili

and

Mohamed Amin Elaguech

submission deadline 31 Mar 2026 | 1 articles | Viewed by 808 | Submission Open

Keywords: nanobiosensors; nanomaterials; age-related diseases; wearable devices; implantable devices

(This special issue belongs to the Section Biosignal Processing)

AI-Driven Advances in Biomedical Diagnosis and Prognosis: Innovations, Applications, and Emerging Trends

edited by

Rizwan Ali Naqvi

, Fayaz A. Ali Dharejo and

Kiran Zahra

submission deadline 31 Mar 2026 | Viewed by 771 | Submission Open

Keywords: artificial intelligence; deep learning; biomedical imaging; biomedical sensing; disease diagnosis; disease prognosis; treatment monitoring; clinical decision-making

(This special issue belongs to the Section Biosignal Processing)

Advances and Clinical Applications of Anterior Segment Imaging Techniques—2nd Edition

edited by

Sang Beom Han

submission deadline 31 Mar 2026 | 1 articles | Viewed by 505 | Submission Open

Keywords: anterior segment; cornea; cataract; conjunctiva; anterior segment imaging; refractive surgery

Computational Intelligence for Healthcare

edited by

Jiaojiao Wang

, Chee Wei Tan and Qingpeng Zhang

submission deadline 31 Mar 2026 | Viewed by 309 | Submission Open

Keywords: artificial intelligence; big data analytics; generative models; pathogen tracking and tracing; chronic disease prediction and management; predictive modeling; bioinformatics; pandemic preparedness; IoT-enabled biosensors; health disparities and ethics; multi-modal data fusion

(This special issue belongs to the Section Biosignal Processing)

Machine Learning and Artificial Intelligence for Biostatistics

edited by Muktar Beshir Ahmed and

Mehdi Neshat

submission deadline 31 Mar 2026 | Viewed by 180 | Submission Open

Keywords: artificial intelligence; machine learning; biostatistics; medical image analysis; biosignal processing; bioinformatics; deep learning; biomedical data science; clinical prediction; statistical learning

(This special issue belongs to the Section Biosignal Processing)

AI in Biomedical Image Segmentation, Processing and Analysis

edited by

Toufique Ahmed Soomro

Lihong Zheng

and Mohammad Ali Moni

submission deadline 31 Mar 2026 | Viewed by 59 | Submission Open

Keywords: artificial intelligence; biomedical imaging; image segmentation; deep learning; medical image processing; radiomics; explainable AI; computer-aided diagnosis

(This special issue belongs to the Section Biosignal Processing)

Preclinical Models in Cardiovascular Disease Research

edited by

Muhammad Riaz

submission deadline 31 Mar 2026 | Viewed by 54 | Submission Open

Keywords: cardiovascular diseases; preclinical cell models; preclinical animal models; iPSCs; organ-on-chip; computational models

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Hot Melt Extrusion and 3D Printing for Enhanced Drug Delivery

edited by

Sateesh Kumar Vemula

submission deadline 31 Mar 2026 | Viewed by 43 | Submission Open

Keywords: 3D printing in pharmaceutics; additive manufacturing in pharmaceuticals; biodegradable polymers; controlled drug release; devices for drug delivery; hot-melt extrusion (HME); implantable drug delivery systems; personalized medicine; regulatory aspects of 3D-printed dosage forms; solid dispersions

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Electromechanical Effects in Biomedical Science: Mechanisms, Materials, and Medical Applications

edited by

Melika Mohammadkhah

Dragan Zoran Marinkovic

and

Paula Pascoal-Faria

submission deadline 31 Mar 2026 | Viewed by 31 | Submission Open

Keywords: electromechanical effects; piezoelectricity; flexoelectricity; bone remodeling and regeneration; mechanobiology; regenerative medicine; smart biomaterials; tissue engineering; biomedical applications; electroactive scaffold; computational modeling of coupled effects; experimental identification of electromechanical effects in tissues; smart drug delivery systems; bioelectronic medicine; smart medical technology; digital twin models for tissue engineering applications

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

AI Advancements in Healthcare: Medical Imaging and Sensing Technologies, 2nd Edition

edited by

Mohammed A. Al-masni

and Kanghyun Ryu

submission deadline 31 Mar 2026 | Viewed by 11 | Submission Open

Keywords: biomedical imaging; biosignals; medical image analysis; abnormalities classification and detection; medical image segmentation; medical image reconstruction; medical image denoising; medical image registration; AI in biomedical systems; computer-aided diagnosis systems

(This special issue belongs to the Section Biosignal Processing)

Stem Cell Immunoengineering

edited by Yun Chang

submission deadline 31 Mar 2026 | Viewed by 9 | Submission Open

Keywords: stem cell; immunoengineering; immune cells; genetic and epigenetic programming; biomaterials; delivery system

(This special issue belongs to the Section Nanobiotechnology and Biofabrication)

Diagnostic Biomedical Image and Processing with Artificial Intelligence and Deep Learning—2nd Edition

edited by

Hongying Meng

and Xinrong Chen

submission deadline 31 Mar 2026 | Viewed by 8 | Submission Open

Keywords: biomedical image; artificial intelligence; deep learning; image processing; medical imaging; computer-assisted diagnosis; pattern recognition; computer vision; bioengineering; medical large language models

(This special issue belongs to the Section Biosignal Processing)

Advanced Fermentation Technologies for Value-Added Production

edited by

Jiahua Shi

submission deadline 31 Mar 2026 | Viewed by 1 | Submission Open

Keywords: food waste; bioconversion; fermentation technology; value-added products; sustainable food system; microbial system; process optimization

(This special issue belongs to the Section Biochemical Engineering)

Biomedical Engineering Strategies for Scoliosis Treatment

edited by Pier Francesco Costici and Sergio De Salvatore

submission deadline 31 Mar 2026 | Submission Open

Keywords: scoliosis; AIS; gait analysis; posture analysis; spine surgery

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Tendon/Ligament and Enthesis Injuries: Repair and Regeneration

edited by Dai Fei Elmer Ker, Jingyu Shi and Bingyang Dai

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1980 | Submission Open

Keywords: tendon; ligament; enthesis; drug delivery; therapeutics; biomaterials; tissue engineering; musculoskeletal animal models

(This special issue belongs to the Section Regenerative Engineering)

Basics and Mechanisms of Different Neuromodulation Devices

edited by

Alaa Abd-Elsayed

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: spinal cord stimulation; peripheral nerve stimulation; deep brain stimulation; vagal nerve stimulation; gastric stimulators; sacral stimulators; neuromodulation; basics; mechanism of action

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

Artificial Intelligence in Biotechnology

edited by Mohammad (Behdad) Jamshidi and Omid Moztarzadeh

submission deadline 20 May 2026 | Viewed by 152 | Submission Open

Keywords: artificial intelligence (AI); biotechnology; machine learning; deep learning; digital twins; multi-omics integration; cancer diagnostics; synthetic biology; internet of bio-nano things (IoBNT); drug discovery

(This special issue belongs to the Section Biosignal Processing)

New Sights of Data Analysis and Digital Model in Biomedicine

edited by

Robert Karpiński

submission deadline 31 May 2026 | Viewed by 447 | Submission Open

Keywords: artificial intelligence in medicine; machine learning for diagnosis; deep learning in medical imaging; predictive analytics in healthcare; AI-powered clinical decision support; natural language processing in biomedicine; data-driven disease diagnosis; digital twins in healthcare; big data in biomedical diagnostics; AI-enhanced biomarker discovery

(This special issue belongs to the Section Biosignal Processing)

Advanced Wearable Sensors for Human Gait Analysis

edited by

Tong Li

, Qingguo Li and Bingfei Fan

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1309 | Submission Open

Keywords: wearable sensors; human movement analysis; rehabilitation; sport science; sensor fusion; machine learning

(This special issue belongs to the Section Biosignal Processing)

Advances in Computational Imaging and Artificial Intelligence for Biomedical and Clinical Applications

edited by Nan Meng,

Jason Pui Yin Cheung

and Junming Shao

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1168 | Submission Open

Keywords: computational imaging; artificial intelligence; deep learning; medical image analysis; medical diagnosis

(This special issue belongs to the Section Biosignal Processing)

Novel Microfluidics Applications in Dental, Oral, and Craniofacial Research

edited by

Xianrui Yang

, Jing Pan, Fan Zhang and

L. Shannon Holliday

submission deadline 3 Jul 2026 | Viewed by 82 | Submission Open

Keywords: dentistry; microfluidics; stem cells; bioengineering; biological mechanisms

AI and Data Analysis in Neurological Disease Management

edited by

Bess Lam

and

Ka-Chun Wong

submission deadline 31 Aug 2026 | Viewed by 109 | Submission Open

Keywords: AI technologies; management of neurological diseases; interdisciplinary approaches; data analysis

(This special issue belongs to the Section Biosignal Processing)

Engineering Intervertebral Disc Models: From Basic Science to Clinical Practice

edited by Lidija Gradišnik

submission deadline 10 Sep 2026 | Viewed by 176 | Submission Open

Keywords: intervertebral disc; disc degeneration; cell isolation; cell cultures; in vitro cell models; 3D bioprinting; treatment

(This special issue belongs to the Section Biomedical Engineering and Biomaterials)

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