Special Issue "Stem Cell and Biologic Scaffold Engineering"
A special issue of Bioengineering (ISSN 2306-5354).
Deadline for manuscript submissions: 28 February 2019
Dr. Panagiotis Mallis
Department of Tissue Engineering and Regenerative Medicine of Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens (BRFAA), Greece
Interests: Tissue Engineered Small Diameter Vascular Grafts; Decellularized human umbilical artery; Mesenchymal Stromal Cells; Hematopoietic Stem Cells; Platelet Rich Plasma
Tissue engineering and regenerative medicine is a rapidly evolving research field, which combines effectively stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold, while the extracellular matrix (ECM) could be preserved intact. Furthermore, biologic scaffolds have been investigated for in vitro potential of whole organ development. Currently, clinical products composed of decellularized matrices such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels are being evaluated in order to be used in human clinical trials.
Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scope, stem cells can be isolated from patients, expanded under Good Manufacturing Practices conditions (GMPs), used for the repopulation of biologic scaffolds, and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds.
Until now, a remarkable effort has been performed by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by combining properly stem cells and biologic scaffolds, thus bringing them one step closer to personalized medicine.
This Special Issue will accept original research articles and comprehensive reviews that deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches.
We look forward to receiving your valuable contributions to this Special Issue.
Dr. Panagiotis Mallis
Manuscript Submission Information
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