Personalized Cardiovascular Medicine: Latest Devices, Surgical Techniques, and Tissue Engineering Strategies—Second Edition

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1540

Special Issue Editors


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Guest Editor
1. Ludwig Boltzmann Institute for Cardiovascular Research at the Center of Biomedical Research and Translational Surgery, Medical University of Vienna, 1090 Vienna, Austria
2. Department of Cardiac Surgery, University Hospital Basel, 4031 Basel, Switzerland
3. Medical Faculty, University of Basel, 4056 Basel, Switzerland
Interests: cardiac surgery; atrial fibrillation; surgical ablation; mechanical circulatory support; cardiopulmonary bypass; animal models; cardiac pacing; cardiac assist devices
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Guest Editor
Ludwig Boltzmann Institute for Cardiovascular Research at the Center of Biomedical Research, Medical University of Vienna, 1090 Wien, Austria
Interests: biomaterial design; tissue decellularization; 3D bioprinting; small diameter vascular grafts; cardiac patch; injectable ECM hydrogels; cell-matrix-interaction; in vitro bioreactor systems; 3D cell culture systems; biomaterial cytotoxicity; animal models
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Guest Editor
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
Interests: cardiovascular tissue engineering; mechanisms of atherogenesis; cell adhesion; cell biomechanics
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Special Issue Information

Dear Colleagues,

In recent years, cardiac medicine, especially surgery, has increasingly developed into a multidisciplinary specialty. Twenty years ago, who would have thought that cardiac surgeons specializing in interventional procedures would be sharing the cardiology OR with cardiologists, vascular surgeons, interventional radiologists, and sometimes even biomedical engineers? New technologies and multidisciplinary strategies in tissue engineering have enabled customized scaffold designs for implants, leading to innovative therapies for today's patients.

The goal of this Special Issue is to collect original papers, reviews, and case reports on new approaches to manufacturing and testing novel implants in cardiovascular research and resulting innovations in surgical therapy as well as peri-operative management. It is intended to be a collection of content from the laboratory to the bedside, publishing promising results from biomedical research, such as new materials, designs, or manufacturing processes of implants, as well as minimally invasive surgical procedures, hybrid approaches, combined multidisciplinary procedures, or new techniques in cardiac surgery. Manuscripts on peri-operative management as well as from collaborating disciplines, e.g., anesthesiology, intensive care, and emergency medicine, are welcome.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Three-dimensional printing of individualized cardiovascular scaffolds and implants;
  • Biodegradable and biologically active prostheses;
  • Novel devices and strategies in the treatment of cardiac disease;
  • Strategies for cardiac regeneration (e.g., cardiac patches);
  • Tissue engineering strategies to create functional implants and create vascular access;
  • Minimally invasive and interventional valve procedures;
  • Open surgical and endovascular management of thoracic aortic disease;
  • Optimized surgical treatment of coronary artery disease (e.g., total arterial revascularization, minimally invasive procedures, and hybrid coronary revascularization);
  • Novel devices and strategies in the treatment of cardiac arrhythmias;
  • Short-term and long-term cardiac assist devices;
  • Hybrid procedures;
  • Peri-operative patient management;
  • Anti-coagulation strategies.

Dr. David Santer
Dr. Karl H. Schneider
Prof. Dr. George Truskey
Guest Editors

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Keywords

  • cardiovascular medicine
  • 3D bioprinting cardiac patch
  • novel scaffold design
  • hybrid procedures
  • minimally invasive cardiac surgery
  • interventional valve replacement
  • aortic surgery
  • aortic interventions
  • valve procedures
  • devices

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Published Papers (1 paper)

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Research

11 pages, 13197 KiB  
Article
First Report on Rigid Plate Fixation for Enhanced Sternal Closure in Minimally Invasive Cardiac Surgery: Safety and Outcomes
by Jules Miazza, Benedikt Reuthebuch, Florian Bruehlmeier, Ulisse Camponovo, Rory Maguire, Luca Koechlin, Ion Vasiloi, Brigitta Gahl, Luise Vöhringer, Oliver Reuthebuch, Friedrich Eckstein and David Santer
Bioengineering 2024, 11(12), 1280; https://doi.org/10.3390/bioengineering11121280 - 16 Dec 2024
Viewed by 1175
Abstract
Introduction: This study reports of the use of a rigid-plate fixation (RPF) system designed for sternal closure after minimally invasive cardiac surgery (MICS). Methods: This retrospective analysis included all patients undergoing MICS with RPF (Zimmer Biomet, Jacksonville, FL, USA) at our institution. We [...] Read more.
Introduction: This study reports of the use of a rigid-plate fixation (RPF) system designed for sternal closure after minimally invasive cardiac surgery (MICS). Methods: This retrospective analysis included all patients undergoing MICS with RPF (Zimmer Biomet, Jacksonville, FL, USA) at our institution. We analyzed in-hospital complications, as well as sternal complications and sternal pain at discharge and at follow-up 7 to 14 months after surgery. Results: Between June and December 2023, 12 patients underwent RPF during MICS, of which 9 patients were included in the study. The median (IQR) age was 64 years (63 to 71) and two patients (22%) were female. All patients underwent aortic valve replacement, with two patients (22%) undergoing concomitant aortic surgery. RPF was successfully performed in all patients. ICU and in-hospital stay were 1 day (1 to 1) and 9 days (7 to 13), respectively. Patients were first mobilized in the standing position on postoperative day 2 (2 to 2). Four patients (44%) required opiates on the general ward. In-hospital mortality was 0%. At discharge, rates of sternal pain, sternal instability or infection were 0%. After a follow-up time of 343.6 days (217 to 433), median pain intensity using the Visual Analog Scale was 0 (0 to 2). Forty-four percent (n = 4) of patients reported pain at rest. No sternal complications (sternal dehiscence, sternal mal-union, sternal instability, superficial wound infections and deep sternal wound infections) were reported. Conclusions: In the evolving landscape of cardiac therapies with incentives to reduce surgical burden, RPF showed safety and feasibility. It might become an important tool for sternal closure in minimally invasive cardiac surgery. Full article
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