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Nano–Bio Interface

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Nanobiotechnology and Biofabrication".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 4279

Special Issue Editors


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Guest Editor
Department of Child Health, The University of Arizona, Phoenix, ZA, USA
Interests: nanoparticle design; gene and drug delivery; pulmonary vascular disease; lung regenerative medicine; cancer diagnosis and therapy
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
The Materials Science and Engineering Program, Department of Mechanical and Materials Engineering, College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45221, USA
Interests: nanoscience in biomedicine; biomedical engineering; biosensing and detecting rare events for safe built environment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The intersection of nanotechnology and biotechnology has opened up a wealth of possibilities in various fields, including medicine, agriculture, environmental science, and materials science. The nano–bio interface, where nanoscale materials and biological systems meet, has become a focal point of research and innovation. This Special Issue of Bioengineering aims to bring together cutting-edge research at the forefront of this exciting and dynamic field.

We invite researchers, scientists, and experts from across the globe to contribute original research articles, reviews, and perspectives that explore the nano–bio interface. Topics of interest for this Special Issue include but are not limited to:

Nanoparticles for Drug Delivery: Novel approaches and developments in using nanoparticles for targeted drug delivery, gene therapy, and personalized medicine.

Biomaterials and Tissue Engineering: Advances in the design and characterization of nanomaterials for tissue engineering, regenerative medicine, and biocompatible implants.

Nanotechnology in Diagnostics: Development of nanoscale biosensors, imaging techniques, and diagnostic tools for early disease detection and monitoring.

Nanotoxicology and Safety Assessment: Investigations into the potential toxicological effects of nanomaterials and the development of safe-by-design nanostructures.

Biological Interactions at the Nanoscale: Understanding the interactions between nanomaterials and biological systems, including cell–nanoparticle interactions and protein adsorption.

Nanoparticles in Agriculture and Food Science: Applications of nanotechnology in agriculture, food safety, and preservation.

Environmental Implications of Nanotechnology: Assessments of the environmental impact of nanomaterials and the development of eco-friendly nanomaterials.

Dr. Zicheng Deng
Prof. Dr. Donglu Shi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanotoxicology
  • drug delivery
  • tissue engineering
  • diagnostics
 

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Related Special Issue

Published Papers (2 papers)

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Research

25 pages, 6918 KiB  
Article
From Green Chemistry to Healthy Environments: Silver Nanoparticles as a Dual Antioxidant and Antibacterial Agents for Advancing Biomedicine and Sustainable Wastewater Treatment
by Hamza Moussa, Sarah Hamid, Amal Mameri, Sabrina Lekmine, Hichem Tahraoui, Mohammed Kebir, Nabil Touzout, Farid Dahmoune, Mohammad Shamsul Ola, Jie Zhang and Abdeltif Amrane
Bioengineering 2024, 11(12), 1205; https://doi.org/10.3390/bioengineering11121205 - 28 Nov 2024
Cited by 7 | Viewed by 1831
Abstract
The green synthesis of silver nanoparticles (AgNPs) using plant extracts is an eco-friendly method with potential for biomedical and environmental applications. This study aims to synthesize silver nanoparticles (SO-AgNPs) using Salvia officinalis L. extract and evaluate their antioxidant and antibacterial properties, positioning them [...] Read more.
The green synthesis of silver nanoparticles (AgNPs) using plant extracts is an eco-friendly method with potential for biomedical and environmental applications. This study aims to synthesize silver nanoparticles (SO-AgNPs) using Salvia officinalis L. extract and evaluate their antioxidant and antibacterial properties, positioning them as candidates for applications in sustainable biomedicine and wastewater treatment. S. officinalis L. extract was used to synthesize AgNPs under optimized conditions, with a 10% extract/AgNO₃ ratio and a reaction time of 180 min. The SO-AgNPs were characterized using ATR-FTIR, XRD, SEM, DLS, and Zeta potential analysis. The antioxidant activity of the extract and SO-AgNPs was evaluated using ABTS+• and DPPH radical scavenging assays. Antibacterial activity was tested against 11 bacterial strains and bacteria isolated from industrial effluent, with minimal inhibitory concentrations (MIC) determined for both the extract and SO-AgNPs. The SO-AgNPs demonstrated potent antioxidant activity, with IC₅₀ values of 0.233 mg/mL and 0.305 mg/mL in the ABTS+• assay, and 0.173 mg/mL and 0.185 mg/mL in the DPPH assay for the extract and SO-AgNPs, respectively. Antibacterial testing showed MIC values of 0.25 mg/mL for SO-AgNPs and between 3.12 and 6.25 mg/mL for S. officinalis L. extract against E. coli, P. aeruginosa, A. baumannii, MRSA, B. cereus, and S. epidermidis. For bacteria isolated from industrial effluent, the MIC values were 0.125 mg/mL for SO-AgNPs and 0.5 mg/mL for the extract. This study highlights the dual antioxidant and antibacterial capabilities of S. officinalis L. extract and SO-AgNPs, demonstrating their potential for use in both biomedical and environmental applications, including wastewater treatment. Full article
(This article belongs to the Special Issue Nano–Bio Interface)
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17 pages, 2259 KiB  
Article
Nanoparticle-Mediated Delivery of Deferasirox: A Promising Strategy Against Invasive Aspergillosis
by Sydney Peppe, Moloud Farrokhi, Evan A. Waite, Mustafa Muhi and Efthymia Iliana Matthaiou
Bioengineering 2024, 11(11), 1115; https://doi.org/10.3390/bioengineering11111115 - 5 Nov 2024
Viewed by 1492
Abstract
Background: Invasive aspergillosis (IA) is a deadly fungal lung infection. Antifungal resistance and treatment side effects are major concerns. Iron chelators are vital for IA management, but systemic use can cause side effects. We developed nanoparticles (NPs) to selectively deliver the iron chelator [...] Read more.
Background: Invasive aspergillosis (IA) is a deadly fungal lung infection. Antifungal resistance and treatment side effects are major concerns. Iron chelators are vital for IA management, but systemic use can cause side effects. We developed nanoparticles (NPs) to selectively deliver the iron chelator deferasirox (DFX) for IA treatment. Methods: DFX was encapsulated in poly(lactic-co-glycolic acid) (PLGA) NPs using a single emulsion solvent evaporation method. The NPs were characterized by light scattering and electron microscopy. DFX loading efficiency and release were assessed spectrophotometrically. Toxicity was evaluated using SRB, luciferase, and XTT assays. Therapeutic efficacy was tested in an IA mouse model, assessing fungal burden by qPCR and biodistribution via imaging. Results: DFX-NPs had a size of ~50 nm and a charge of ~−30 mV, with a loading efficiency of ~80%. Release kinetics showed DFX release via diffusion and bioerosion. The EC50 of DFX-NPs was significantly lower (p < 0.001) than the free drug, and they were significantly less toxic (p < 0.0001) in mammalian cell cultures. In vivo, NP treatment significantly reduced Af burden (p < 0.05). Conclusion: The designed DFX-NPs effectively target and kill Af with minimal toxicity to mammalian cells. The significant in vivo therapeutic efficacy suggests these NPs could be a safe and effective treatment for IA. Full article
(This article belongs to the Special Issue Nano–Bio Interface)
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