Cell Bioprocess Engineering: Basic Fundamentals and Applications

Dear Colleagues,

Industrial Cell Culture to produce human biologics has progressed from a “dream” in the early 1980s to an estimated 19 billion dollar (USD) annual industry with a projected growth rate of 7 percent annually. Congruent with this financial growth is the productivity and scale and productivity of the cell culture processes.  As human biologics progress from specialty products to, potentially, near commodities, such as basic antibiotics, significant pressure will continue to build on further increase productivity and decrease operating costs.  This success in biologics has also contributed toward the prediction that cell therapy (i.e. cells are the product) and cultured meat are economically viable.  While the ongoing commercial success of biologics is the result of many scientific and technological advancements, large scale, economic cell culture has been vital, and is even more important for cell therapy and cultured meat.  In this collection of articles, we wish to highlight the key technological challenges, and progress addressing these issues not just in biologics production but also cell therapy and cultured meat. 

Since this is a special issues focused on Bioprocessing, obvious topics will be included, but not limited to: modes of operation of the bioprocess, cell densities and associated challenges, specialized media and associated costs, product/byproduct removal, and mixing including nutrient delivery.   

Prof. Dr. Jeffrey J. Chalmers
Guest Editor

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• cell culture
• bioprocess engineering
• cell separation
• biologics
• cellular therapies