Tumor Mechanobiology and Translational Insights
A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Cellular and Molecular Bioengineering".
Deadline for manuscript submissions: 15 January 2026 | Viewed by 160
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mechanobiology has transformed our understanding of cancer by illuminating the role of biophysical forces and mechanical interactions in tumor initiation, progression, and metastasis. From the altered stiffness and morphology of the extracellular matrix (ECM) to the dynamic mechanotransduction pathways within cancer cells, the physical microenvironment profoundly shapes cancer behavior. These mechanical forces not only drive hallmark processes such as invasion, intravasation, and extravasation but also influence immune evasion and therapeutic resistance.
This Special Issue invites research and review articles exploring the intersection of mechanics and biology in cancer. Topics of interest include the following:
- Biophysical and biochemical interactions within the tumor microenvironment.
- ECM remodeling and its impact on tumor progression.
- Mechanical forces driving metastasis: invasion, intravasation, circulation, and extravasation.
- Cellular and molecular mechanisms of mechanotransduction in cancer.
- Advanced imaging and computational modeling of tumor mechanics.
- Personalized approaches to cancer therapy informed by mechanobiology.
- Interplay between mechanical forces and immune responses in cancer.
By highlighting interdisciplinary research, this Special Issue aims to uncover new avenues for therapeutic interventions and a deeper understanding of the physical forces driving cancer.
Dr. Yousef Javanmardi
Guest Editor
Manuscript Submission Information
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Keywords
- tumor mechanobiology
- tumor microenvironment
- mechanotransduction
- ECM remodeling
- tissue mechanics
- translational mechanobiology
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