The Role of Formalin-Fixed Paraffin-Embedded Tissue in Biomedical Engineering

Dear Colleagues,

We are inviting manuscript submission for a Special Issue on “The Role of Formalin-Fixed Paraffin-Embedded Tissue in Biomedical Engineering”.

Recent advances in functional genetic analysis of malignant tumors have led to the identification of many cancer-related genes. The use of next-generation sequencers (NGS) to carry out genetic analysis of somatic mutations derived from pathological/cytological material, such as malignant tumors, is providing important information for determining disease treatment strategies.

Histopathological diagnosis using formalin-fixed paraffin-embedded (FFPE) has been performed by hematoxylin-eosin staining and immunohistochemical staining. However, in the treatment of tumors with known genetic abnormalities, the application of molecular targeted drags has been evaluated after examining the expression of various molecules by immunochemical staining. On the other hand, it is controversial whether FFPE can maintain a satisfactory quality to carry out NGS, avoiding degradation of nucleic acids based on prolonged storage in paraffin blocks and damage to nucleic acids due to formalin immobilization.

Therefore, the use of surgically removed archival FFPE tissue specimens for genomic analysis and research for further treatment is a very important and interesting tool.

I hope that this project will serve as an opportunity to expand our knowledge of methods and research applications to preserve the quality of FFPE from the stage of histopathological examination, to extract good nucleic acids and use them for genetic analysis and research.

Dr. Tomomi Fujii
Guest Editor

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