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Applied Sciences
Special Issues
Effects of Caffeine on Human Health
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Effects of Caffeine on Human Health

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Food Science and Technology".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 1907

Special Issue Editor

Dr. Susan Hall

E-Mail Website
Guest Editor
School of Pharmacy and Medical Sciences, Griffith University, Southport, Gold Coast, Australia
Interests: neuroinflammation and neurodegeneration; caffeine and health

Special Issue Information

Dear Colleagues,

Caffeine is one of the most widely consumed beverages worldwide, and is found in many different food sources.  Given what we know of the bioactive nature of caffeine, the study of the effects of caffeine consumption on various health conditions is imperative to elucidate its effects in a range of health conditions.  Therefore, we are pleased to invite you to submit an article investigating the effects of caffeine on health.

The aim of this Special Issue is to present recent advancements in the understanding of the effects caffeine consumption has on the prevention and treatment of human health conditions. In this Special Issue, original research articles and reviews are welcome.  Research topics may include but are not limited to the following:

  • Review articles outlining the latest evidence for beneficial or detrimental effects of caffeine on human health;
  • The evaluation of caffeine on biomarkers of chronic disease in humans;
  • The evaluation of caffeine in animal models of disease;
  • In vitro mechanistic studies investigating caffeine’s role in human health;
  • Epidemiological studies investigating the effects of caffeine on human health.

I look forward to receiving your contributions.

Dr. Susan Hall
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Caffeine
  • Human disease
  • Biomarkers

Published Papers (1 paper)

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Research

10 pages, 599 KiB  
Article
Effects of Caffeine and 5-Caffeoylquinic Acid on Blood Cell In Vitro Cytokine Production in Response to Lipopolysaccharide Stimulation
by Lluis Rodas, Sonia Martínez, Aina Riera-Sampol, Hannah J. Moir and Pedro Tauler
Appl. Sci. 2022, 12(14), 7322; https://doi.org/10.3390/app12147322 - 21 Jul 2022
Viewed by 1443
Abstract
Previous in vitro studies the have suggested anti-inflammatory properties of caffeine. Coffee is also rich in phenolic acids with several potential health benefits (chlorogenic acids), mainly 5-caffeoylquinic acid (5-CQA). The aim of the present study was to determine the effect of caffeine and [...] Read more.
Previous in vitro studies the have suggested anti-inflammatory properties of caffeine. Coffee is also rich in phenolic acids with several potential health benefits (chlorogenic acids), mainly 5-caffeoylquinic acid (5-CQA). The aim of the present study was to determine the effect of caffeine and 5-CQA, using concentrations comparable to typical human consumption, on LPS-induced cytokine production in whole blood in vitro cultures. Whole blood samples (n = 10) were stimulated for 24 h with LPS in the presence of caffeine or 5-CQA. The concentrations of various cytokines, malondialdehyde (MDA) and adenosine-3′,5′-cyclic monophosphate (cAMP) were determined in the culture media. Significant effects of caffeine were found only for the stimulated production of TNF-α (p = 0.014) and cAMP (p = 0.001). However, only the highest caffeine concentration (50 μM) induced lower TNF-α (p = 0.016) and higher cAMP (p = 0.006) levels in comparison to the control. The 5-CQA only influenced the stimulated production of IL-6 (p = 0.002), with lower values for the highest 5-CQA concentrations (2 μM: p = 0.012; 20 μM: p < 0.001). Neither caffeine (p = 0.227) nor 5-CQA (p = 0.259) influenced MDA concentrations. In conclusion, both caffeine and 5-CQA exerted limited in vitro anti-inflammatory effects. For caffeine, these effects were attained with high physiological concentrations. However, for 5-CQA, supraphysiological concentrations were needed. Full article
(This article belongs to the Special Issue Effects of Caffeine on Human Health)
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