Advances in Cancer Prognostics and Therapeutic Approaches in Oral Oncology
A special issue of Applied Sciences (ISSN 2076-3417).
Deadline for manuscript submissions: 30 November 2025 | Viewed by 6
Special Issue Editors
Interests: oral pathology; oral medicine; oral diagnosis; oncology; biomarkers; epithelial–mesenchymal transition
Special Issue Information
Dear Colleagues,
The escalating global burden of oral squamous cell carcinoma (OSCC), particularly its tendency for late-stage diagnosis, requires deeper understanding of its biological drivers and therapeutic resistance mechanisms. Despite advances in treatment modalities, the five-year survival rates for advanced OSCC remain alarmingly low, reflecting persistent deficiencies in prognostic precision and targeted therapeutic approaches. This persistent clinical challenge underscores the urgent need for multidisciplinary research to improve patient outcomes.
This Special Issue aims to compile high-impact original research and comprehensive reviews examining the complex clinical, histopathological and molecular landscape of oral cancers. Particular emphasis will be placed on identifying novel prognostic biomarkers, including emerging histopathological indicators of disease aggressiveness, while also exploring fundamental mechanisms of therapeutic resistance such as tumor microenvironment interactions and metabolic adaptations. The edition aims to highlight more innovative treatment strategies, ranging from targeted molecular therapies to advanced immunomodulation approaches.
We specifically seek contributions that elucidate the interplay between tumor biology and clinical outcomes, with potential to transform current management paradigms. By integrating cutting-edge research across these domains, this collection aims to address critical knowledge gaps in OSCC management. The ultimate goal is to facilitate development of personalized treatment algorithms and optimize healthcare resource utilization through evidence-based approaches.
We invite submissions of original research articles, reviews, and translational studies that advance our understanding of prognostic stratification and therapeutic innovation in oral squamous cell carcinoma.
I look forward to receiving your contributions.
Dr. Everton De Morais
Dr. Roseana De Almeida Freitas
Guest Editors
Manuscript Submission Information
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Keywords
- oral cancer
- carcinogenesis
- diagnosis
- cancer heterogeneity
- biomarkers
- targeted therapy
- immunotherapy
- therapy resistance
- prognosis
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