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Personalized Dentistry and Orthodontics

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Dentistry and Oral Sciences".

Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 1073

Special Issue Editor


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Guest Editor
Department of Orthodontics, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
Interests: orthodontics; biomarkers; mini-implants; orthognathic surgery; cleft lip and palate; craniofacial orthodontics; morphometrics

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to the use of personalized dentistry and orthodontics. Personalized medicine, in general, is an emerging field in diagnostics and therapeutics that uses the patient’s genetic background to apply an individual approach to the prevention, diagnosis and treatment of a disease. Likewise, in the field of dentistry and orthodontics, recent advances in genome, proteome and metabolome analysis open new insights in the knowledge of a patient’s individual profile and individual dental and orthodontic treatment.

We are inviting submissions in the form of original research papers, as well as literature reviews or systematic reviews, focusing on the integration of dentistry and orthodontics with the basic sciences to understand the underlying cellular and molecular mechanisms and biochemical pathways that need to be revealed.

Some clinical examples include the identification of skeletal-class-II-associated and skeletal-class-III-associated genes, which can facilitate the precise prediction of the craniofacial growth of an individual patient based on their genomic profile. Moreover, some biomarkers were found to provide a quantitative method of assessing a child’s skeletal maturity, which in turn is associated with the efficiency of orthodontic and functional treatment of growing patients. Furthermore, several bone metabolism biochemical markers are involved in orthodontic tooth movement, while others have been associated with orthodontically induced inflammatory root resorption or periodontal inflammation. It is also noteworthy that peri-miniscrew implant GCF biomolecule alterations were observed and correlated to mini-implant success or failure.

Despite the investigations, the clinical applicability of the use of omics technology and biomedicine in dentistry and orthodontics is still limited; nevertheless, a rapid development in this field is expected in order to optimize orthodontic diagnosis, treatment progress and delivery of the best dental and orthodontic treatment outcome.

The collection of papers of this Special Issue will provide an overview of the most innovative efforts in this field to advance precision patient care.

We look forward to receiving your work.

Dr. Athina Chatzigianni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

10 pages, 250 KiB  
Article
The Role of Bone Alkaline Phosphatase and Osteocalcin in Saliva as Indicators of Skeletal Maturity in Children
by Georgios Kouvelis, Sotiria Davidopoulou, Olga-Elpis Kolokitha, Moschos A. Papadopoulos and Athina Chatzigianni
Appl. Sci. 2023, 13(24), 13012; https://doi.org/10.3390/app132413012 - 6 Dec 2023
Viewed by 858
Abstract
The aim of this study was to investigate the levels of bone alkaline phosphatase (BALP) and osteocalcin (OC) in the saliva of growing patients of different maturation levels. The sample consisted of 55 patients (34 females and 21 males of 7–16 years old). [...] Read more.
The aim of this study was to investigate the levels of bone alkaline phosphatase (BALP) and osteocalcin (OC) in the saliva of growing patients of different maturation levels. The sample consisted of 55 patients (34 females and 21 males of 7–16 years old). Two milliliters of saliva were collected and BALP and OC levels were assessed. Skeletal age was estimated using the cervical vertebral maturation method (CVM). The relationship between the biomarkers’ concentration in saliva and skeletal age was examined with the Spearman’s coefficient “ρ” (rho). Correlations between skeletal age groups and BALP and OC concentrations were assessed with the Kruskal–Wallis or the Mann–Whitney tests. No statistically significant differences in the levels of BALP (p = 0.568) and OC (p = 0.996) in saliva were identified according to the patient’s skeletal age. The use of BALP and OC levels in saliva seems to be dubious for skeletal growth assessment. However, slightly differentiated levels of those biomarkers, especially of BALP, through the different maturation stages, with higher concentrations at the pubertal phase, have been noticed. More studies are needed to clarify the exact potential role of these biomarkers as predictors of pubertal onset. Full article
(This article belongs to the Special Issue Personalized Dentistry and Orthodontics)
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