Selective Modulation of Kinase: Translation from Bench to Bedside

Dear Colleagues,

Protein phosphorylation regulates most cellular functions, whereas abnormal phosphorylation is a hallmark or a pathogenetic mechanism of disease. Protein kinases are now considered the second most essential kind of drug targets besides G-protein-coupled receptors. Studying protein kinases and their inhibitors is promising for developing new approaches to treatment of chronic non-communicable diseases.

Dysregulation of signalling pathways occurs in many pathological states. Dozens of small molecule kinase inhibitors have received approval by the FDA. There is continuing effort to develop drug treatment strategies targeting both protein kinases themselves and their multiple substrates. This Special Issue will bring together original research and review articles on studies related to discovering new inhibitors, molecular mechanisms, and therapeutic targets associated with signaling pathways that use protein kinases.

Discoveries of new synthetic and natural protein kinase inhibitors will be discussed to advance translational potential of research. The Special Issue will present new therapeutic strategies aimed at alleviating pathological conditions and contributing to organ protection. Priority will be given to interdisciplinary research in the fields of cardiovascular sciences, neurosciences, and immunology.

Dr. Nina D. Anfinogenova
Guest Editor

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