Insights into Red Blood Cell Aging: In Vivo and in Vitro

Dear Colleagues,

The aging of red blood cells (RBCs), both in vivo and in vitro, is a multifaceted biological phenomenon that is considered an issue of special scientific and clinical interest. Oxidative stress and defective adenosine triphosphate metabolism are the main driving forces of RBC alterations. Aging-related processes lead to significant metabolic and structural erythrocyte changes, including global biochemical and biophysical alteration, and remodeling of the cell membrane and cytoplasm composition, and, as a result, provoke deterioration in erythrocyte functionality and clearance of senescent cells.

For this Special Issue, we encourage original research submissions and reviews. We expect to receive contributions addressing biophysical, biochemical, and physiological aspects of RBC aging in vivo and in vitro. Analyses and evaluations of the diverse senescence markers of erythrocyte aging are also welcome. These issues will be discussed as simulations, or from a clinical or experimental point of view.

Dr. Gregory Barshtein
Guest Editors

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