Special Issue "Nanoparticles in Sensing and Labelling"

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Nanotechnology and Applied Nanosciences".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editor

Prof. Dr. Johann Michael Köhler
Website SciProfiles
Guest Editor
Department of Physical Chemistry and Microreaction Technology, Institute for Micro- and Nano-technologies/Institute for Chemistry and Biotechnology, Weimarer Str. 32, D-98693 Ilmenau, Germany
Interests: microfluidic synthesis of metal nanoparticles; electrical properties of nanoparticles; non-spherical and composite nanoparticles; nanoparticles in sensing and labelling
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The convergence between technical and natural principles is an urgent challenge for developing powerful and sustainable devices and materials. This insight demands shrinking of our devices, sensors, and labels down to the microscopic or even the molecular scale, on the one hand. On the other hand, it demands making materials intelligent, functionalizing them, and arranging the atoms and molecules of materials into universally handable and applicable entities. Functional micro- and nanoparticles meet these requirements. They help to overcome the borderline between material and device and become able to uptake, convert, and deliver information. Research in recent years has shown that these features can be implemented into nanoparticles and make them useful microtools as labels and transducers. This Special Issue will reflect the state-of-the-art in this field and discuss new promising strategies for synthesis and application of micro- and nanoparticles in physics, chemistry, material development, biomedicine, and cell technology.

Prof. Dr. Johann Michael Köhler
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • particle synthesis
  • labeling
  • sensing
  • signal transduction
  • surface functionalization
  • composite particles
  • multicomponent particles
  • particle-based communication

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

Open AccessFeature PaperArticle
2-LED-µSpectrophotometer for Rapid On-Site Detection of Pathogens Using Noble-Metal Nanoparticle-Based Colorimetric Assays
Appl. Sci. 2020, 10(8), 2658; https://doi.org/10.3390/app10082658 - 12 Apr 2020
Abstract
Novel point-of-care compatible methods such as colorimetric assays have become increasingly important in the field of early pathogen detection. A simple and hand-held prototype device for carrying out DNA-amplification assay based on plasmonic nanoparticles in the colorimetric detection is presented. The low-cost device [...] Read more.
Novel point-of-care compatible methods such as colorimetric assays have become increasingly important in the field of early pathogen detection. A simple and hand-held prototype device for carrying out DNA-amplification assay based on plasmonic nanoparticles in the colorimetric detection is presented. The low-cost device with two channels (sample and reference) consists of two spectrally different light emitting diodes (LEDs) for detection of the plasmon shift. The color change of the gold-nanoparticle-DNA conjugates caused by a salt-induced aggregation test is examined in particular. A specific and sensitive detection of the waterborne human pathogen Legionella pneumophila is demonstrated. This colorimetric assay, with a simple assay design and simple readout device requirements, can be monitored in real-time on-site. Full article
(This article belongs to the Special Issue Nanoparticles in Sensing and Labelling)
Show Figures

Graphical abstract

Open AccessArticle
A Mechanism of Gold Nanoparticle Aggregation by Immunoglobulin G Preparation
Appl. Sci. 2020, 10(2), 475; https://doi.org/10.3390/app10020475 - 09 Jan 2020
Abstract
Conjugates of gold nanoparticles (GNPs) and antibodies are widely used in various fields of biochemistry and microbiology. However, the procedure for obtaining such conjugates remains precarious, and the properties of conjugates differ significantly for different antibody clones. One of the most common problems [...] Read more.
Conjugates of gold nanoparticles (GNPs) and antibodies are widely used in various fields of biochemistry and microbiology. However, the procedure for obtaining such conjugates remains precarious, and the properties of conjugates differ significantly for different antibody clones. One of the most common problems is the aggregation of GNPs in the course of their conjugation with antibodies. This article considers an example of the conjugation of monoclonal antibodies with non-stable aggregating product. The composition of the antibody preparation was studied using electrophoresis, asymmetrical flow field-flow fractionation, and ultracentrifugation. It was shown that the component that causes the aggregation of the GNPs is the light chains of immunoglobulins that appear due to the spontaneous decay of the antibodies. After separation of the fraction with a molecular weight of less than 30 kDa, stable conjugates of antibodies with GNPs were obtained. The high functional activity of the obtained conjugates was confirmed by immunochromatography. Full article
(This article belongs to the Special Issue Nanoparticles in Sensing and Labelling)
Show Figures

Figure 1

Back to TopTop