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Applied Sciences
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Titanium and Its Compounds: Properties and Innovative Applications
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Titanium and Its Compounds: Properties and Innovative Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: 10 September 2025 | Viewed by 648

Special Issue Editors

Dr. Aleksandra Radtke

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Guest Editor
Department of Inorganic and Coordination Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland
Interests: titania; nanomaterials; nanocoatings; implants; hydroxyapatite; photodegradation; biointegration; biological activity; CVD; ALD
Special Issues, Collections and Topics in MDPI journals
Dr. Adrian Topolski

E-Mail Website1 Website2
Guest Editor
Department of Inorganic and Coordination Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland
Interests: titania nanotubes; nanomaterials; surface modification; methylene blue; photodegradation; catalysis; platinum complexes; kinetics; substitution
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Titanium is one of the most interesting metals today. It has applications in medicine, catalysis, photocatalysis, in the production of fine and corrosion-resistant alloys, and in other fields such as chemistry and material science.

The hundreds of possible applications and a huge number of titanium compounds studied and announced in scientific journals, at conferences, and noted in patents have encouraged us to organize a Special Issue devoted to this amazing metal and its compounds—specifically, on its chemistry, properties, and applications.

This Special Issue is a great opportunity to gather together scientists involved in research on titanium and its compounds, and to prepare a collection of a group of scientific papers related to titanium, its alloys, chemical compounds, and composites.

If you are studying titanium and/or its compounds, we strongly encourage and welcome your contribution to this Special Issue. 

Dr. Aleksandra Radtke
Dr. Adrian Topolski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • titanium
  • titanium alloys
  • titanium (IV) coordination compounds
  • composites
  • nanomaterials
  • properties
  • applications

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Published Papers (2 papers)

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Research

14 pages, 4095 KiB  
Article
Alkali-Treated, Nanostructured-Micro-Porous Titanium Surfaces Enhance Osteogenic Differentiation of Adipose Derived Stem Cells
by Aniruddha Vijay Savargaonkar, Emma Holloway and Ketul C. Popat
Appl. Sci. 2025, 15(9), 5061; https://doi.org/10.3390/app15095061 - 2 May 2025
Viewed by 201
Abstract
Ensuring effective integration between the material of an implant and bone is critical to orthopedic implants’ success in the long term. A major issue with dense materials is the mechanical mismatch between them and the bone, which leads to improper osseointegration. Porous implants [...] Read more.
Ensuring effective integration between the material of an implant and bone is critical to orthopedic implants’ success in the long term. A major issue with dense materials is the mechanical mismatch between them and the bone, which leads to improper osseointegration. Porous implants have presented a solution to this issue as they are able to retain material properties in addition to decreasing mismatches. In order to make implants more biomimetic and to match the micro-/nano hierarchy of bone, several surface modifications have been explored in the literature. Hydrothermal treatment in an alkali media on dense titanium has demonstrated higher differentiation of adipose-derived stem cells to osteogenic lineages. In this study, we fabricated nanostructures using hydrothermal treatment in an alkali medium on micro-porous titanium surfaces and evaluated the adhesion, proliferation, and differentiation of adipose derived stem cells to osteoblasts. The nanostructured-micro-porous titanium surfaces displayed enhanced osteogenic differentiation of adipose derived stem cells. Therefore, they have the potential to be used as surfaces for the fabrication of orthopedic implants. Full article
(This article belongs to the Special Issue Titanium and Its Compounds: Properties and Innovative Applications)
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14 pages, 5812 KiB  
Article
Biomechanical and Clinical Validation of a Modulus-Graded Ti-Nb-Sn Femoral Stem for Suppressing Stress Shielding in Total Hip Arthroplasty
by Yu Mori, Hidetatsu Tanaka, Hiroaki Kurishima, Ryuichi Kanabuchi, Naoko Mori, Keisuke Sasagawa and Toshimi Aizawa
Appl. Sci. 2025, 15(9), 4827; https://doi.org/10.3390/app15094827 - 26 Apr 2025
Cited by 1 | Viewed by 280
Abstract
Stress shielding remains a major concern in cementless total hip arthroplasty (THA) due to the stiffness mismatch between femoral stems and surrounding bone. This study investigated the biomechanical and clinical performance of a novel Ti-33.6Nb-4Sn (Ti-Nb-Sn) alloy stem with a graded Young’s modulus [...] Read more.
Stress shielding remains a major concern in cementless total hip arthroplasty (THA) due to the stiffness mismatch between femoral stems and surrounding bone. This study investigated the biomechanical and clinical performance of a novel Ti-33.6Nb-4Sn (Ti-Nb-Sn) alloy stem with a graded Young’s modulus achieved through localized heat treatment. A finite element model (FEM) of the Ti-Nb-Sn stem, incorporating experimentally validated Young’s modulus gradients, was constructed and implanted into a patient-specific femoral model. Stress distribution and micromotion were assessed under physiological loading conditions. Clinical validation was performed by evaluating radiographic outcomes at 1 and 3 years postoperatively in 40 patients who underwent THA using the Ti-Nb-Sn stem. FEM analysis showed low micromotion at the proximal press-fit region (4.89 μm rotational and 11.74 μm longitudinal), well below the threshold for osseointegration and loosening. Stress distribution was concentrated in the proximal region, effectively reducing stress shielding distally. Clinical results demonstrated minimal stress shielding, with no cases exceeding Grade 3 according to Engh’s classification. The Ti-Nb-Sn stem with a gradient Young’s modulus provided biomechanical behavior closely resembling in vivo conditions and showed promising clinical results in minimizing stress shielding. These findings support the clinical potential of modulus-graded Ti-Nb-Sn stems for improving implant stability in THA. Full article
(This article belongs to the Special Issue Titanium and Its Compounds: Properties and Innovative Applications)
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