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Explainable AI in Medical Imaging: Toward Transparent and Trustworthy Diagnostic Systems

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: 20 November 2025

Special Issue Editors


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Guest Editor
Department of Computer Engineering & Informatics, University of Patras, 26504 Patras, Greece
Interests: medical imaging; deep learning; breast cancer diagnosis; robotics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Electrical & Computer Engineering Department, University of Patras, 26504 Patras, Greece
Interests: medical image processing; breast cancer detection; pattern recognition
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Electrical & Computer Engineering Department, University of Patras, 26504 Patras, Greece
Interests: medical imaging; pattern recognition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Artificial intelligence (AI) can be readily integrated into medical imaging to vastly improve diagnostics; however, the black box nature of many AI models, particularly deep learning systems, hinders clinical adoption. The field of explainable AI (XAI) represents an important area of both research and application that offers routes toward transparency, interpretability, and trust in automated decision-making systems.

This Special Issue will cover new methods, frameworks, and applications that improve the interpretability of AI systems in medical imaging. Contributions that focus on theoretical foundations, algorithmic developments, evaluation strategies, and clinical validations of XAI techniques are welcomed. We are particularly interested in submissions which achieve a compromise of high performance along with important insights for clinicians, radiologists, and medical professionals.

Dr. Athanasios Koutras
Dr. Dermatas Evangelos
Dr. Ioanna Christoyianni
Dr. George Apostolopoulos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • XAI
  • medical imaging
  • interpretable AI
  • deep learning
  • machine learning
  • clinical decision support
  • model transparency
  • healthcare AI

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Published Papers

This special issue is now open for submission.
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