Epigenetic Regulation and Chromatin Dynamics in Stem Cell Innovation: From Mechanisms to Clinical Translation

Dear Colleagues,

Stem cell research has emerged as a cornerstone of regenerative medicine, driven by breakthroughs in epigenetic regulation and chromatin biology. Recent studies highlight how histone post-translational modifications (e.g., acetylation, methylation) and chromatin-associated enzymatic processes (e.g., DNA repair, chromatin remodeling) critically govern stem cell pluripotency, differentiation, and reprogramming. These mechanisms not only deepen our understanding of cellular identity but also address challenges in scalability and clinical translation. This Special Issue invites contributions that bridge cutting-edge epigenetics with stem cell innovation, emphasizing interdisciplinary approaches to advance therapeutic applications.

This Special Issue aims to compile high-quality research and reviews that explore the interplay between epigenetic regulation, chromatin dynamics, and stem cell technologies. By focusing on mechanistic insights and translational innovations, the Special Issue aligns with Applied Sciences’ scope of fostering multidisciplinary solutions to real-world biomedical challenges. We aim to collect at least 10 articles, which may be compiled into a printed volume upon achieving this milestone.

We welcome original research articles and reviews on topics including (but not limited to) the following:

1. Epigenetic control of stem cell fate (e.g., CRISPR/dCas9-mediated editing of histone marks, non-coding RNAs).
2. Chromatin enzymology (e.g., roles of helicases, topoisomerases, and histone-modifying enzymes).
3. Translational applications (e.g., organoid systems, biomaterial-guided differentiation, precision medicine).
4. Ethical and regulatory frameworks for epigenetic-based therapies.

By integrating these themes, this Special Issue will advance our mechanistic understanding and clinical applications, aligning with Applied Sciences’ mission to foster impactful, multidisciplinary research.

We look forward to receiving your contributions.

Prof. Dr. Ming Pei
Guest Editor

Dr. Maoshen Sun
Guest Editor Assistant

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