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AI-Based Biomedical Signal Processing—2nd Edition

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 152

Special Issue Editors


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Guest Editor
Department of Information Engineering, Università Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy
Interests: bioengineering; biomedical signal processing; biostatistics; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Informatics, Systems and Communication, University of Milano-Bicocca, 20126 Milano, Italy
Interests: brain computer interfacing; electrophysiological signal processing, analysis and classification; motor movement and imagery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Artificial intelligence (AI) is inspiring new solutions to challenges typically present in the healthcare field. AI-based innovative tools have revealed their effectiveness in different steps of the biomedical signal processing blockchain, including biomedical signal (i) acquisition, (ii) preprocessing, (iii) feature engineering and (iv) classification/interpretation. AI-based methods may find solutions to biomedical signal processing challenges by integrating sensors and acquisition systems. Moreover, they can represent new approaches to preprocess, characterize, classify, and interpret biomedical signals. These solutions may be essential in all fields of healthcare, including cardiology, neurology, endocrinology, movement analysis, physical activity monitoring, assistive robotics, telemedicine, and others.

This Special Issue aims to collect original research papers and/or reviews on AI-based methods for biomedical signal processing.

Main topics include, but are not limited to, the following:

  • Intelligent sensors, devices and instruments for biomedical signal acquisition;
  • AI-based biomedical signal preprocessing;
  • Machine learning for biomedical feature extraction and selection;
  • Knowledge engineering for feature interpretation;
  • AI-based clinical decision making in healthcare;
  • AI-based precision medicine;
  • Data analytics and mining for clinical decision support;
  • Ethics of AI in healthcare.

Dr. Agnese Sbrollini
Dr. Aurora Saibene
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • artificial intelligence
  • biomedical signal processing
  • filtering and denoising
  • machine and deep learning
  • clinical decision-support systems
  • cognitive computing
  • computer vision
  • interpretability

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Published Papers (1 paper)

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22 pages, 975 KiB  
Systematic Review
Machine Learning to Recognise ACL Tears: A Systematic Review
by Julius Michael Wolfgart, Ulf Krister Hofmann, Maximilian Praster, Marina Danalache, Filippo Migliorini and Martina Feierabend
Appl. Sci. 2025, 15(9), 4636; https://doi.org/10.3390/app15094636 - 22 Apr 2025
Viewed by 142
Abstract
Machine learning-based tools are becoming increasingly popular in clinical practice. They offer new possibilities but are also limited in their reliability and accuracy. The present systematic review updates and discusses the existing literature regarding machine learning algorithm-based identification of cruciate ligament injury on [...] Read more.
Machine learning-based tools are becoming increasingly popular in clinical practice. They offer new possibilities but are also limited in their reliability and accuracy. The present systematic review updates and discusses the existing literature regarding machine learning algorithm-based identification of cruciate ligament injury on radiographic images. PubMed was searched for articles containing machine learning algorithms related to cruciate ligament injury recognition. No additional filters or time constraints were used. All eligible studies were accessed by hand. From the 115 articles initially retrieved, 29 articles were finally included. Only one study included the posterior cruciate ligament (PCL). Deep learning algorithms in the form of convolutional neural networks (CNNs) were most frequently used. Many studies presented CNNs that identified binary decision classes of regular and torn anterior cruciate ligaments (ACLs) with a best sensitivity of 0.98, a specificity of 0.99, and an AUC ROC of 1.0. Other studies expanded the decision classes to partially torn ACLs or reconstructed ACLs, usually at the cost of sensitivity and specificity. Deep learning algorithms are excellent for identifying ACL injuries, tears, or postoperative status after reconstruction on MRI images. They are much faster but only sometimes better than the human reviewer. While the technology seems ready, barriers to ethical and legal issues and clinicians’ refusals must be overcome to some extent. It can be firmly assumed that artificial intelligence will have a future contribution in the diagnosis of cruciate ligament injuries. Full article
(This article belongs to the Special Issue AI-Based Biomedical Signal Processing—2nd Edition)
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