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Applied Sciences
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Applications of Ultrasonic Technology in Biomedical Sciences
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Applications of Ultrasonic Technology in Biomedical Sciences

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: 10 August 2025 | Viewed by 1994

Special Issue Editors

Prof. Dr. Constanza Rubio Michavila

E-Mail Website
Guest Editor
Centro de Tecnologías Físicas, Universitat Politècnica de València, 46022 Valencia, Spain
Interests: ultrasound propagation in complex media; ultrasonic metamaterials; use of ultrasonic techniques for materials characterization; ultrasonic NDT; medical application of ultrasonic techniques for diagnosis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sergio Castiñeira-Ibáñez

E-Mail Website
Guest Editor
Applied Physics Department, Universitat Politècnica de València, 46022 València, Spain
Interests: acoustics materials; noise control; sound propagation in complex media; composite materials and biomaterials; use of ultrasonic techniques for materials characterization; numerical modeling
Special Issues, Collections and Topics in MDPI journals
Dr. Daniel Tarrazó-Serrano

E-Mail Website
Guest Editor
Centro de Tecnologías Físicas, Universitat Politècnica de València, 46022 Valencia, Spain
Interests: acoustics materials; noise control; sound propagation in complex media, composite materials, and biomaterials; use of ultrasonic techniques for materials characterization; medical application of ultrasonic techniques for diagnosis; modelling ultrasonic devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on emerging applications and the improvement of existing techniques in the field of medical sciences. In biomedicine, ultrasound is used to manipulate cells or particles in suspension, enhance the sensitivity of biosensors, generate images, characterize the viscoelastic properties of biological fluids and tissues, employ holographic lenses for transcranial ultrasound and drug delivery, utilize HIFU therapies and monitor other ablation techniques. This Special Issue seeks contributions that explore  innovations in and the refinement of existing practices, in order to advance the future of ultrasound in the medical field. We encourage submissions that present advances regarding the application of ultrasound field in the biomedical sciences.

Prof. Dr. Constanza Rubio Michavila
Dr. Sergio Castiñeira-Ibáñez
Dr. Daniel Tarrazó-Serrano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ultrasound
  • biomedicine
  • medical diagnosis
  • biosensor

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Published Papers (2 papers)

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Research

13 pages, 1613 KiB  
Article
Morphological Analysis of US Treated PANC-1 Spheroids
by Martina Ricci, Mattia Dimitri, Martina Serio and Andrea Corvi
Appl. Sci. 2025, 15(4), 1707; https://doi.org/10.3390/app15041707 - 7 Feb 2025
Viewed by 592
Abstract
This study investigates the impact of low-intensity continuous ultrasound (LICU) on pancreatic adenocarcinoma (PANC-1) spheroids, emphasizing morphological and volumetric transformations. PANC-1 spheroids were cultured and treated with LICU across frequencies from 1 to 5 MHz. Cell viability and mortality were analyzed through Calcein [...] Read more.
This study investigates the impact of low-intensity continuous ultrasound (LICU) on pancreatic adenocarcinoma (PANC-1) spheroids, emphasizing morphological and volumetric transformations. PANC-1 spheroids were cultured and treated with LICU across frequencies from 1 to 5 MHz. Cell viability and mortality were analyzed through Calcein AM/PI staining, while volumetric and morphological changes were quantified across frequencies from 2 to 4 MHz using advanced imaging techniques and computational tools, including a custom Python OpenCv Library, AnaSP 3.0, a MATLAB based open source tool. Notably, a frequency of 3.5 MHz yielded optimal outcomes, also achieving a reduction in spheroid volume and mortality while minimizing disgregation, a factor linked to metastasis risk. These findings underscore LICU’s potential as an effective therapeutic strategy, balancing tumor reduction with the preservation of structural cohesion. The study establishes a methodological framework for optimizing LICU parameters, presenting a less invasive avenue for improving therapeutic outcomes in pancreatic cancer treatment. Full article
(This article belongs to the Special Issue Applications of Ultrasonic Technology in Biomedical Sciences)
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16 pages, 2394 KiB  
Article
Effects of Varying Caffeine Dosages and Consumption Timings on Cerebral Vascular and Cognitive Functions: A Diagnostic Ultrasound Study
by Min-Ki Choi, Hee-Seul Ahn, Da-Eun Kim, Da-Seul Lee, Chan-Sol Park and Chang-Ki Kang
Appl. Sci. 2025, 15(4), 1703; https://doi.org/10.3390/app15041703 - 7 Feb 2025
Viewed by 1104
Abstract
Caffeine is consumed owing to its stimulatory effects; however, its excessive intake triggers adverse effects. Herein, we analyzed changes in physiological cerebrovascular and cognitive functions following the consumption of 100 and 200 mg of caffeine in healthy adults after 0/30/60 min to ascertain [...] Read more.
Caffeine is consumed owing to its stimulatory effects; however, its excessive intake triggers adverse effects. Herein, we analyzed changes in physiological cerebrovascular and cognitive functions following the consumption of 100 and 200 mg of caffeine in healthy adults after 0/30/60 min to ascertain appropriate caffeine consumption habits. The peak systolic velocity (PSV), pulse wave velocity (PWV), and common carotid artery (CCA) diameter were measured using diagnostic ultrasound. Cognitive function was evaluated using the accuracy rate and response time on the two-back task. Percutaneous oxygen saturation (SpO2) and heart rate (HR) were assessed using patient monitoring systems. After consuming 100 mg of caffeine, systolic blood pressure (SBP) increased (p > 0.05) and SpO2 and accuracy rate improved by 30 min (p = 0.018 and p = 0.356) but declined by 60 min (p = 0.924 and p = 0.055). HR and response time continuously decreased (p = 0.209 and p = 0.061, respectively), while PWV showed no change (p > 0.05). After consuming 200 mg of caffeine, SBP (p < 0.05), diastolic blood pressure (p = 0.004 and p = 0.820), and SpO2 (p = 0.002 and p = 0.666) increased significantly, while the accuracy rate (p = 0.634 and p = 0.055, respectively) and response time (p < 0.05) decreased. PWV remained unchanged (p > 0.05). The results revealed distinct dose-dependent patterns on physiological and cognitive changes, with SBP and SpO2 exhibiting greater changes when a higher dose was consumed in a short duration. Although moderate caffeine intake may support vascular health and cognitive function, excessive intake reduces blood flow, alters vascular elasticity, and impairs cognitive activation. These findings highlight the need for guidelines to ensure safe and effective caffeine consumption. Full article
(This article belongs to the Special Issue Applications of Ultrasonic Technology in Biomedical Sciences)
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