Fighting Radical Species in Human Health: Mitigating Radical Species with Natural and Synthetic Compounds

Dear Colleagues,

Oxidative and nitrosative stress, also called the bad radical species, play a critical role in many diseases. For example, identifying new therapeutic strategies capable of modifying the course of neurodegenerative diseases is currently one of the major goals for researchers of this field. Developing novel pharmaceutical compounds bearing antioxidant properties will significantly enhance our understanding of their roles against the bad radical species in biological systems. It will help us to discover powerful compounds that eventually help patients suffering from diseases that involve radical species production. Eventually, these may lead to the design of novel therapeutic strategies, offer insight into neurodegenerative diseases, and lead to more effective treatments that will positively impact clinic outcomes.

There is evidence for an alternative therapeutic role for drugs with natural and non-natural antioxidative properties for efficient neuroprotection of oxidative stress in various models. Natural antioxidant compounds such as curcumin, resveratrol, and epigallocatechin-3-gallate are a class of compounds abundant in plants. Non-natural antioxidant compounds are a class of compounds such as butylated hydroxyanisole, tert-butylhydroquinonem and ferrostatin-1 (the first inhibitor of Ferroptosis cell death), created from a well-defined synthetic route.

We hope to stimulate our broad multidisciplinary investigators from neuroscience, chemical biology, plant biology, and drug discovery to provide a platform via this Special Issue that invites investigators to report their latest discoveries dealing with: (i) natural and non-natural small molecules, phenolic extracts; (ii) in vivo and/or in vitro mechanism of action of antioxidants, (iii) natural or synthetic antioxidants and their relevance to health and disease, (iv) relationships between antioxidant properties and human health promotion, and (v) protein aggregation and radical scavengers.

Dr. Rachid Skouta
Guest Editor

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