Commemorative Issue of Antioxidants Dedicated to Peter Eckl
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Aberrant Oxidation of Biomolecules".
Deadline for manuscript submissions: closed (15 May 2021) | Viewed by 26178
Special Issue Editors
Special Issue Information
Dear Colleagues,
Peter ECKL (born in 1954), who held a professorship at the Department of Biosciences at the University of Salzburg, Austria started his scientific career in the field of radiation research. During his stay as post-doc in the laboratory of Randy Jirtle at Duke University (Durham, North Carolina, USA), Peter Eckl successfully developed a protocol for the serum-free culture of proliferating primary rat hepatocytes to be used in geno- and cytotoxicity testing. Among the first applications of this in vitro system, Peter Eckl, in collaboration with the 4-hydoxynoenenal (HNE) pioneer Hermann Esterbauer, studied the genotoxic potential of lipid peroxidation-derived 4-hydroxyalkenals. This early study revealed a strong mutagenic potential of HNE in primary hepatocytes exceeding that seen in other, non-hepatic test systems; a finding which emphasized the metabolic aspect of HNE toxicity. From this time on, the subject oxidative stress, and in particular lipid peroxidation and “the cell biology of HNE”, became most influential to Peter Eckl’s scientific career. Research conducted in the “Eckl Lab” comprised studies on the effects of oxidative stress and HNE in cerebral endothelial cells and astrocytes, investigations on the genotoxicity of beta-carotene breakdown products, and studies on the antioxidant/anti-mutagenic properties of vitamins and compounds of ethno-pharmacological interest. The finding of ferritin cytotoxicity directed his research interests to iron-related effects, which, not unexpectedly, also turned out to be intimately linked with lipid-peroxidation. Most of the recent research was dealing with mechanisms by which oxidatively stressed cells manage to eliminate lipid-peroxidation products, especially highly-crosslinked aggregates of HNE-modified proteins. Peter Eckl’s long standing fascination for the oxidative stress mediator HNE became also manifest by his dedicated activity for the HNE-club, an international association of scientists affiliated to oxidative stress research. The next biannual meeting of the HNE-club will take place from 15th–17th of June, 2020 in Milan, Italy (https://sites.unimi.it/HNECLUB/hne2020/).
Professor Peter ECKL has been the Editorial Board member of Antioxidants since 2015. This commemorative issue of Antioxidants aims at compiling recent progress in the still expanding field of oxidative stress and lipid peroxidation covering its manifold biological and medical implications as well as aspects of antioxidant defence. Submissions of previously unpublished manuscripts (original research or reviews) are welcome. It is planned to receive submission until end of September 2020. Manuscripts will be published on an ongoing basis after being processed.
Dr. Nikolaus Bresgen
Prof. Dr. Werner Siems
Guest Editors
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