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Review

Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications

1
Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417614335, Iran
2
School of Biology, College of Science, University of Tehran, Tehran 1417614335, Iran
3
Center of Excellence in NanoBiomedicine, University of Tehran, Tehran 1417614335, Iran
4
Research Center of Food Technology and Agricultural Products, Department of Food Toxicology, Standard Research Institute, Karaj 3158777871, Iran
5
Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy
6
UNESCO Chair on Interdisciplinary Research in Diabetes, University of Tehran, Tehran 1417614335, Iran
*
Authors to whom correspondence should be addressed.
Antioxidants 2020, 9(12), 1228; https://doi.org/10.3390/antiox9121228
Received: 10 November 2020 / Revised: 29 November 2020 / Accepted: 1 December 2020 / Published: 4 December 2020
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcription factor that maintains the cell’s redox balance state and reduces inflammation in different adverse stresses. Under the oxidative stress, Nrf2 is separated from Kelch-like ECH-associated protein 1 (Keap1), which is a key sensor of oxidative stress, translocated to the nucleus, interacts with the antioxidant response element (ARE) in the target gene, and then activates the transcriptional pathway to ameliorate the cellular redox condition. Curcumin is a yellow polyphenolic curcuminoid from Curcuma longa (turmeric) that has revealed a broad spectrum of bioactivities, including antioxidant, anti-inflammatory, anti-tumor, and anti-viral activities. Curcumin significantly increases the nuclear expression levels and promotes the biological effects of Nrf2 via the interaction with Cys151 in Keap1, which makes it a marvelous therapeutic candidate against a broad range of oxidative stress-related diseases, including type 2 diabetes (T2D), neurodegenerative diseases (NDs), cardiovascular diseases (CVDs), cancers, viral infections, and more recently SARS-CoV-2. Currently, the multifactorial property of the diseases and lack of adequate medical treatment, especially in viral diseases, result in developing new strategies to finding potential drugs. Curcumin potentially opens up new views as possible Nrf2 activator. However, its low bioavailability that is due to low solubility and low stability in the physiological conditions is a significant challenge in the field of its efficient and effective utilization in medicinal purposes. In this review, we summarized recent studies on the potential effect of curcumin to activate Nrf2 as the design of potential drugs for a viral infection like SARS-Cov2 and acute and chronic inflammation diseases in order to improve the cells’ protection. View Full-Text
Keywords: Nrf2; curcumin; Keap1; viral infection; acute and chronic inflammation diseases; bioavailability; oxidative stress; COVID-19; pharmacological applications Nrf2; curcumin; Keap1; viral infection; acute and chronic inflammation diseases; bioavailability; oxidative stress; COVID-19; pharmacological applications
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MDPI and ACS Style

Rahban, M.; Habibi-Rezaei, M.; Mazaheri, M.; Saso, L.; Moosavi-Movahedi, A.A. Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications. Antioxidants 2020, 9, 1228. https://doi.org/10.3390/antiox9121228

AMA Style

Rahban M, Habibi-Rezaei M, Mazaheri M, Saso L, Moosavi-Movahedi AA. Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications. Antioxidants. 2020; 9(12):1228. https://doi.org/10.3390/antiox9121228

Chicago/Turabian Style

Rahban, Mahdie, Mehran Habibi-Rezaei, Mansoureh Mazaheri, Luciano Saso, and Ali A. Moosavi-Movahedi 2020. "Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications" Antioxidants 9, no. 12: 1228. https://doi.org/10.3390/antiox9121228

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