Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
10.6
6.0
Journals
Antioxidants
Special Issues
The Role of Nutrition and Exercise in the Prevention and...
share announcement

The Role of Nutrition and Exercise in the Prevention and Treatment of Oxidative Stress-Associated Diseases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 7864

Special Issue Editors

Prof. Dr. Dejan Reljic

E-Mail Website
Guest Editor
1. Experimental Nutritional and Sports Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany
2. Sports Science and Performance Physiology Research Group, Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany
Interests: exercise physiology; sports medicine; physical activity; muscle physiology; cardiorespiratory fitness; chronic diseases; nutrition; obesity; metabolic syndrome
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yurdagül Zopf

E-Mail Website
Guest Editor
1. Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
2. Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
3. German Center Immunotherapy (DZI), University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
Interests: cachexia syndrome; malnutrition; muscle function; atrophy and therapy; food intolerance and food allergy; celiac disease and non-celiac gluten sensitivity; chronic inflammatory bowel disease
Special Issues, Collections and Topics in MDPI journals
Dr. Hans Joachim Herrmann

E-Mail Website
Guest Editor
1. Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
2. Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
3. German Center Immunotherapy (DZI), University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany
Interests: nutrition; exercise; sport physiology; muscle physiology; metabolic syndrome; gastrointestinal diseases

Special Issue Information

Dear Colleagues,

Over the last decades, non-communicable chronic diseases (NCDs) have been dramatically increasing in their prevalence and constitute the most common causes of death around the globe. Therefore, the exploration and development of effective measures to prevent and control NCDs have become an important public health issue. Many of the most common chronic diseases, such as cardiovascular disease, type 2 diabetes and cancer, are associated with increased inflammation and oxidative stress. In this context, it is well accepted that lifestyle habits, including nutrition and physical activity, play a key role in the prevention of chronic conditions. Moreover, nutritional modifications and targeted exercise interventions are crucial cornerstones in NCD treatment. It has been shown, for example, that a good level of cardiorespiratory fitness is associated with a better overall health status and a reduced risk of mortality in apparently healthy individuals, as well as in clinical populations. In addition, both a proper diet and regular exercise and can help reduce medication needs and improve the quality of life in patients with a variety of chronic issues.

The goal of this Special Issue is to provide an updated overview and new knowledge on the role of nutrition, physical activity and exercise in the prevention and treatment of oxidative stress-related NCDs. Both original research and review papers are welcome for article collection. Authors are invited to submit the findings of their recent investigations relating the effects of diet, nutritional supplements, physical activity or exercise on oxidative stress, inflammation and associated outcomes in chronic conditions, particular (but not limited to) cardiometabolic diseases and cancer. We aim to present new discoveries in the field and to stimulate a fruitful discussion of innovative approaches to prevent and treat NCDs with nutrition and exercise.

Prof. Dr. Dejan Reljic
Prof. Dr. Yurdagül Zopf
Dr. Hans Joachim Herrmann
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • physical activity
  • exercise
  • oxidative stress
  • chronic diseases
  • cardiovascular disease
  • type 2 diabetes
  • cancer
  • inflammation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

25 pages, 4048 KiB  
Article
Physical Exercise Alleviates Oxidative Stress and Autonomic Dysregulation in a Rat Model of Inflammatory Bowel Disease
by Brenda Lois Barros dos Santos, Alda Cássia Alves da Silva, Juliana Soares Severo, Bruno de Sousa Barbosa, Maisa Campêlo de Sousa, Francisco Assis dos Santos Moreira, Lucas Estevão de Sousa, Heron Silva Soares, Antônio Klingem Leite de Freitas, Francisco Leonardo Torres-Leal, Paulo Correia-de-Sá, Armênio Aguiar dos Santos and Moisés Tolentino Bento da Silva
Antioxidants 2025, 14(3), 328; https://doi.org/10.3390/antiox14030328 - 10 Mar 2025
Viewed by 655
Abstract
Inflammatory bowel disease (IBD) induces immunological and autonomic imbalances. Exercise is a beneficial strategy for controlling IBD symptoms. We investigated the role of exercise on gastrointestinal (GI) motility changes and autonomic parameters in rats with ileitis. Rats were divided into control, ileitis, and [...] Read more.
Inflammatory bowel disease (IBD) induces immunological and autonomic imbalances. Exercise is a beneficial strategy for controlling IBD symptoms. We investigated the role of exercise on gastrointestinal (GI) motility changes and autonomic parameters in rats with ileitis. Rats were divided into control, ileitis, and exercise+ileitis groups. Ileitis was induced by TNBS (40 mM, intraileally). The exercise was swimming (1 h/day/4 weeks, 5%/bw). We assessed eating behaviour and oxidative stress. Body composition was assessed by bioimpedance. Autonomic balance and ECG parameters were measured by an electrocardiogram (ECG). Gastrointestinal motility was evaluated using the phenol red technique. In terms of body composition, total body water (TBW), body mass index (BMI), and fat-free mass (FFM) were higher in the ileitis group (216.80 ± 11.44 mL; 24.09 ± 2.15 g/cm2; 287.1 ± 14.66 g) (p < 0.05) vs. control rats (130.06 ± 28.23 mL; 16.38 ± 2.50 g/cm2; 193 ± 42.21 g) and exercise prevented (91.33 ± 12.33 mL; 11.73 ± 0.47 g/cm2; 133.8 ± 16.82 g) (p < 0.05) these changes. The exercise+ileitis group induces a reduction (p < 0.05) in gastric retention vs. ileitis and control (11.22 ± 1.91% vs. 35.17 ± 1.01% and 33.96 ± 1.77%). Ileitis increased intestinal retention in the duodenum (46.3 ± 2.56% vs. 24.98 ± 1.78%) and jejunum (34.22 ± 2.33% and 34.72 ± 2.83% vs. 47.32 ± 1.48%) (p < 0.05) and decreased intestinal retention in the ileum (p < 0.05) vs. the control group. Exercise+ileitis prevented (p < 0.05) changes in the duodenum (24.96 ± 1.66% vs. 46.3 ± 2.56%) and ileum (40.32 ± 3.75% vs. 14.08 ± 0.88%). Ileitis induces high MDA levels (p < 0.05) vs. control rats (4.43 ± 0.69 vs. 2.15 ± 0.12 nmol/mg of the tissue). This effect was prevented (p < 0.05) in the exercise+ileitis group (2.75 ± 0.21 vs. 4.43 ± 0.69 nmol/mg of the tissue). We observed a reduction in the LF component (p < 0.05) in the ileitis group vs. control group (31.32 ± 3.99 vs. 43.43 ± 3.86). The correlation indicated a stronger interrelationship between the autonomic parameter and intestinal retention in the ileum (r: 0.68; p: 0.04). The current study suggests intestinal ileitis alters GI motility and autonomic balance, and physical exercise can represent an essential non-pharmacological approach to IBD treatment. Full article
(This article belongs to the Special Issue The Role of Nutrition and Exercise in the Prevention and Treatment of Oxidative Stress-Associated Diseases)
►▼ Show Figures

Figure 1

14 pages, 1657 KiB  
Article
Effects of Sulforaphane Treatment on Skeletal Muscle from Exhaustive Exercise-Induced Inflammation and Oxidative Stress Through the Nrf2/HO-1 Signaling Pathway
by Ruheea Taskin Ruhee, Sihui Ma and Katsuhiko Suzuki
Antioxidants 2025, 14(2), 210; https://doi.org/10.3390/antiox14020210 - 12 Feb 2025
Cited by 1 | Viewed by 1099
Abstract
Skeletal muscle is primarily involved in exercise performance and health promotion. Sulforaphane (SFN) is a naturally occurring isothiocyanate that indirectly activates the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), thus inducing the expression of Nrf2 target genes, including antioxidant enzymes. This [...] Read more.
Skeletal muscle is primarily involved in exercise performance and health promotion. Sulforaphane (SFN) is a naturally occurring isothiocyanate that indirectly activates the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), thus inducing the expression of Nrf2 target genes, including antioxidant enzymes. This study aimed to identify the effects of a single dose of SFN administration on exhaustive exercise-induced inflammation and oxidative stress in skeletal muscle tissue and elucidate the underlying mechanisms. Thirty-six mice were divided into four groups: control, SFN, exercise (Ex), and SFN + Ex. The SFN group and SFN + Ex group received SFN orally (50 mg/kg body weight) 2 h before the running test. Exercise significantly reduced plasma glucose levels, while the SFN-treated group exhibited a smaller reduction. Acute exhaustive exercise increased the expression of pro-inflammatory cytokines in muscle tissue, while the SFN + Ex group exhibited significantly reduced expression of pro-inflammatory cytokines. The gene expression of Nrf2 and its target enzymes, including heme oxygenase (HO)-1, superoxide dismutase (SOD)-1, catalase (CAT), and glutathione peroxidase (GPx)-1, was measured in the gastrocnemius and soleus muscle tissue. Compared with the Ex group, the SFN + Ex group showed upregulated expression of all these parameters, including Nrf2. SFN treatment reduced acute exhaustive exercise-induced oxidative stress and inflammation via activation of the Nrf2/HO-1 signaling pathway. Full article
(This article belongs to the Special Issue The Role of Nutrition and Exercise in the Prevention and Treatment of Oxidative Stress-Associated Diseases)
►▼ Show Figures

Figure 1

13 pages, 304 KiB  
Article
Effects of Regular Exercise on the Biochemical, Oxidative, and Inflammatory Profiles and Quality of Life in Older Spaniards with Metabolic Syndrome
by Margalida Monserrat-Mesquida, Maria Magdalena Quetglas-Llabrés, Cristina Bouzas, Silvia García, David Mateos, Lucía Ugarriza, Cristina Gómez, Josep A. Tur and Antoni Sureda
Antioxidants 2024, 13(4), 450; https://doi.org/10.3390/antiox13040450 - 11 Apr 2024
Cited by 1 | Viewed by 2066
Abstract
Metabolic syndrome increases the risk of developing diabetes and cardiovascular disease. The regular practice of physical activity is a crucial factor for healthy aging and for controlling and preventing chronic diseases. To assess the effects of regular physical activity on the biochemical and [...] Read more.
Metabolic syndrome increases the risk of developing diabetes and cardiovascular disease. The regular practice of physical activity is a crucial factor for healthy aging and for controlling and preventing chronic diseases. To assess the effects of regular physical activity on the biochemical and inflammatory profiles, as well as the quality of life of older adults diagnosed with metabolic syndrome. Participants (aged 55–70 years; living in the Balearic Islands, Spain) were divided into two groups (n = 50 each) according to the degree of physical activity measured by metabolic equivalents of task (METs). Anthropometric parameters, blood pressure, biochemical and hematological parameters, and inflammatory biomarkers were measured. Beck Depression Inventory and adherence to the Mediterranean diet questionnaires, as well as the Dietary Inflammatory Index, chair test, health-related quality of life (HRQoL), and Rapid Assessment of Physical Activity, were also determined. The characterization of the patients was similar in both groups, showing a homogeneous sample. The group with the highest METs experienced a decrease in depression and an increase in the intensity of physical activity. Adherence to the Mediterranean diet and HRQoL physical dimensions increased in participants with the highest METs, also showing a decrease in glycemia and glycosylated hemoglobin values. Inflammatory biomarkers, including tumor necrosis factor alpha, interleukin-6, interleukin-1β, and osteoprotegerin, decreased in patients practicing more physical activity. High levels of physical activity are related to a healthier lifestyle, characterized by high adherence to the Mediterranean diet, decreased depressive behavior, oxidative stress, and inflammatory status in older people with metabolic syndrome. Full article
(This article belongs to the Special Issue The Role of Nutrition and Exercise in the Prevention and Treatment of Oxidative Stress-Associated Diseases)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

15 pages, 1061 KiB  
Review
The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract
by Monika Pinkas and Tomasz Brzozowski
Antioxidants 2024, 13(4), 413; https://doi.org/10.3390/antiox13040413 - 28 Mar 2024
Cited by 6 | Viewed by 3196
Abstract
Recently discovered irisin, a member of the myokines family, is a potential mediator of exercise-induced energy metabolism and a factor promoting browning of the white adipose tissue. Recent evidence indicates that this myokine, released from contracting muscles, can mediate the beneficial effects of [...] Read more.
Recently discovered irisin, a member of the myokines family, is a potential mediator of exercise-induced energy metabolism and a factor promoting browning of the white adipose tissue. Recent evidence indicates that this myokine, released from contracting muscles, can mediate the beneficial effects of exercise on health. Irisin may be a potential therapeutic agent against obesity and has been shown to play an important role in the protection of various cells, tissues, and organs due to its anti-inflammatory, antioxidative, and anti-cancer properties. Our aim was to review the recent experimental and clinical studies on irisin and its expression, release into the bloodstream, tissue targets, and potential contribution to the protective effects of exercise in the gastrointestinal tract. Particular emphasis was placed on inflammatory bowel disease, intestinal ischemia/reperfusion injury, periodontitis, and other digestive tract disorders, including carcinogenesis. Overall, irisin holds significant potential as a novel target molecule, offering a safe and therapeutic approach to treating various gastrointestinal diseases. Full article
(This article belongs to the Special Issue The Role of Nutrition and Exercise in the Prevention and Treatment of Oxidative Stress-Associated Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop