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Beyond Weight Loss: The Role of Exercise and Nutrition in Managing Morbid Obesity and Related Comorbidities

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 803

Special Issue Editor


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Guest Editor
1. Experimental Nutritional and Sports Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany
2. Sports Science and Performance Physiology Research Group, Hector-Center for Nutrition, Exercise and Sports, Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany
Interests: exercise physiology; sports medicine; physical activity; muscle physiology; cardiorespiratory fitness; chronic diseases; nutrition; obesity; metabolic syndrome
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Special Issue Information

Dear Colleagues,

Morbid obesity is a complex and multifaceted condition that significantly increases the risk of developing severe comorbidities, including cardiovascular disease, type 2 diabetes, and metabolic dysfunction. Given the rising prevalence of obesity-related health complications, there is an urgent need for effective, evidence-based treatment strategies. Physical activity and nutrition play a pivotal role in both the prevention and management of morbid obesity and its associated comorbidities. Research suggests that structured exercise and targeted dietary interventions can not only facilitate weight loss but also improve metabolic health, reduce inflammation, and enhance overall well-being. However, many questions remain regarding the optimal exercise modalities, nutritional strategies, and their combined effects on long-term health outcomes.

The goal of this Special Issue is to provide a comprehensive update on and novel insights into the role of exercise and nutrition in treating morbid obesity and mitigating the related health risks. I invite researchers to submit original research or up-to-date review articles that explore the physiological, metabolic, and clinical effects of dietary interventions, exercise programs, and their synergistic impact on obesity-related comorbidities.

This Special Issue aims to present latest findings in the field and foster discussions on innovative and integrative approaches for managing morbid obesity and improving patient outcomes.

Yours sincerely,

Prof. Dr. Dejan Reljic
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • morbid obesity
  • exercise interventions
  • nutritional strategies
  • metabolic health
  • obesity-related comorbidities

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Published Papers (1 paper)

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Review

16 pages, 2100 KiB  
Review
Common Peroneal Nerve Paralysis Following Rapid Weight Loss—A Case Report and Literature Review
by Laura-Elena Cucu, Gabriela Popescu, Alexandra Maștaleru, Emilian Bogdan Ignat, Cristina Grosu, Lenuța Bîrsanu and Maria Magdalena Leon
Nutrients 2025, 17(11), 1782; https://doi.org/10.3390/nu17111782 - 24 May 2025
Viewed by 620
Abstract
Common peroneal nerve neuropathy at the fibular head secondary to weight loss is known as slimmer’s paralysis. Although this pathology has long been documented in medical literature, it has gained more clinical significance in recent years due to the global rise in obesity [...] Read more.
Common peroneal nerve neuropathy at the fibular head secondary to weight loss is known as slimmer’s paralysis. Although this pathology has long been documented in medical literature, it has gained more clinical significance in recent years due to the global rise in obesity and the increasing pursuit of rapid weight loss methods. While case reports exist in the current literature, there are limited data regarding its optimal management. This study summarizes all reported cases of common peroneal nerve paralysis after weight loss and reports one additional case, exploring disease mechanisms as well as diagnostic and therapeutic strategies. A literature review was conducted on the platforms PubMed, Google Scholar, and EMBASE. A total of 380 patients were included. Laterality of neuropathy was specified in 297 (78.16%) patients: 285 (95.96%) with unilateral neuropathy and 12 (4.04%) with bilateral neuropathy. A total of 19 (5.00%) patients had sudden onset, and in 145 (38.16%) of cases, the Tinel’s sign was positive. Additionally, 373 (98.16%) patients underwent nerve conduction studies, demonstrating the fibular head as the site of injury. MRI or ultrasound imaging of the knee is indicated to exclude compressive etiology. A total of 302 (79.47%) cases were treated surgically and 42 (11.58%) conservatively, predominantly with favorable outcomes, regardless of the therapeutic approach chosen. Although the predominance of surgically treated cases in the literature limits definitive treatment recommendations, conservative management appears appropriate when an extended recovery time is acceptable, while surgical decompression is indicated in cases showing no improvement after 3 months. Full article
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