Modulation of Autophagy by Dietary Polyphenols: Mechanisms and Health Benefits

Dear Colleagues,

Recent years have provided plenty of evidence that health benefits of dietary polyphenols are mediated not only by their potent antioxidant and antiinflammatory properties, but also via the modulation of autophagy. Different forms of autophagy play a critical role in cellular homeostasis, while related genetic and acquired defects lead to disease. For this reason, the process of autophagy has been recognized as a pharmacological target. However, little is known about the molecular mechanisms underlying the crosstalk of polyphenol-mediated pathways with autophagy machinery.

We invite you to submit your latest research or review article to this Special issue that will gather novel evidence on the signaling and/or epigenetic mechanisms triggered by dietary polyphenols in various models of human disease characterized by oxidative imbalance and/or inflammation. In particular, papers addressing the relationship between antioxidant and anti-inflammatory pathways and autophagy are welcome.

The Special Issue is not restricted to a specific pathology but will focus on novel and consolidating insights into mechanisms of autophagy regulation and the pharmacology of natural flavonoids and related compounds found in dietary sources. 

We are looking forward to your contribution to this fast evolving research area. 

Dr. Elzbieta Janda
Guest Editor

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