Antioxidants and Oxidative Stress at the Crossroads of Autophagy and Ferroptosis
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 117
Special Issue Editors
Interests: toxicology; quinone oxidoreductase; polyphenols; autophagy; energy metaboilism; hepatic steatosis
Special Issues, Collections and Topics in MDPI journals
Interests: iron metabolism; mitochondria bioenergetics; ferroptosis; cancer; cancer therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress plays a pivotal role as both a trigger of ferroptosis and a central regulator of autophagy. Both processes can be finely tuned by natural and synthetic antioxidants, which exert dual and context-dependent effects. For instance, polyphenols and other bioactive compounds may either promote or inhibit autophagy and ferroptosis depending on their concentration, the cellular redox state, and the specific tissue or tumor microenvironment. By influencing iron metabolism, glutathione balance, lipid peroxidation, and reactive oxygen species (ROS) signaling, they act at the crossroads of these two pathways. This ability enables them to either protect normal cells from oxidative injury or, conversely, sensitize tumor cells to ferroptosis and/or autophagy through interconnected mechanisms.
This Special Issue welcomes both original research and comprehensive reviews exploring the biological activities of natural and synthetic antioxidants, with particular attention to the molecular mechanisms underlying their regulation of oxidative stress, ferroptosis, and autophagy. Priority will be given to contributions that identify direct molecular targets of antioxidants and clarify how they influence the delicate balance between cytoprotection and cell death with translational and therapeutic implications. However, high-quality manuscripts addressing any aspect of these processes will also be considered.
Dr. Elzbieta Janda
Dr. Flavia Biamonte
Guest Editors
Manuscript Submission Information
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Keywords
- antioxidants
- oxidative stress
- ferroptosis
- autophagy
- molecular mechanisms
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