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Modulation of Autophagy in Cancer Cells by Dietary Polyphenols
Review

Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects

1
Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, University Complutense of Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain
2
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain
3
Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Instituto de Salud Carlos III, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
Antioxidants 2021, 10(2), 142; https://doi.org/10.3390/antiox10020142
Received: 30 October 2020 / Revised: 16 January 2021 / Accepted: 17 January 2021 / Published: 20 January 2021
Polyphenols represent a group of secondary metabolites of plants which have been analyzed as potent regulators of multiple biological processes, including cell proliferation, apoptosis, and autophagy, among others. These natural compounds exhibit beneficial effects and protection against inflammation, oxidative stress, and related injuries including metabolic diseases, such as cardiovascular damage, obesity and diabetes, and neurodegeneration. This review aims to summarize the mechanisms of action of polyphenols in relation to the activation of autophagy, stimulation of mitochondrial function and antioxidant defenses, attenuation of oxidative stress, and reduction in cell apoptosis, which may be responsible of the health promoting properties of these compounds. View Full-Text
Keywords: polyphenols; autophagy; mechanisms; oxidative stress; inflammation; disease models polyphenols; autophagy; mechanisms; oxidative stress; inflammation; disease models
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MDPI and ACS Style

García-Aguilar, A.; Palomino, O.; Benito, M.; Guillén, C. Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects. Antioxidants 2021, 10, 142. https://doi.org/10.3390/antiox10020142

AMA Style

García-Aguilar A, Palomino O, Benito M, Guillén C. Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects. Antioxidants. 2021; 10(2):142. https://doi.org/10.3390/antiox10020142

Chicago/Turabian Style

García-Aguilar, Ana, Olga Palomino, Manuel Benito, and Carlos Guillén. 2021. "Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects" Antioxidants 10, no. 2: 142. https://doi.org/10.3390/antiox10020142

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