Modulation of Autophagy in Cancer Cells by Dietary Polyphenols
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Department of Medical Chemistry, Medical University of Gdansk, 80-211 Gdansk, Poland
2
Department of Histology, Medical University of Gdansk, 80-211 Gdansk, Poland
*
Author to whom correspondence should be addressed.
Antioxidants 2021, 10(1), 123; https://doi.org/10.3390/antiox10010123
Received: 27 November 2020
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Revised: 13 January 2021
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Accepted: 14 January 2021
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Published: 16 January 2021
(This article belongs to the Special Issue Modulation of Autophagy by Dietary Polyphenols: Mechanisms and Health Benefits)
The role of autophagy is to degrade damaged or unnecessary cellular structures. Both in vivo and in vitro studies suggest a dual role of autophagy in cancer—it may promote the development of neoplasms, but it may also play a tumor protective function. The mechanism of autophagy depends on the genetic context, tumor stage and type, tumor microenvironment, or clinical therapy used. Autophagy also plays an important role in cell death as well as in the induction of chemoresistance of cancer cells. The following review describes the extensive autophagic cell death in relation to dietary polyphenols and cancer disease. The review documents increasing use of polyphenolic compounds in cancer prevention, or as agents supporting oncological treatment. Polyphenols are organic chemicals that exhibit antioxidant, anti-inflammatory, anti-angiogenic, and immunomodulating properties, and can also initiate the process of apoptosis. In addition, polyphenols reduce oxidative stress and protect against reactive oxygen species. This review presents in vitro and in vivo studies in animal models with the use of polyphenolic compounds such as epigallocatechin-3-gallate (EGCG), oleuropein, punicalgin, apigenin, resveratrol, pterostilbene, or curcumin and their importance in the modulation of autophagy-induced death of cancer cells.
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Keywords:
autophagy; cancer cells; dietary polyphenols; epigallocatechin gallate; apigenin; oleuropein; punicalgin; resveratrol; pterostilbene; flavonoids
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MDPI and ACS Style
Musial, C.; Siedlecka-Kroplewska, K.; Kmiec, Z.; Gorska-Ponikowska, M. Modulation of Autophagy in Cancer Cells by Dietary Polyphenols. Antioxidants 2021, 10, 123. https://doi.org/10.3390/antiox10010123
AMA Style
Musial C, Siedlecka-Kroplewska K, Kmiec Z, Gorska-Ponikowska M. Modulation of Autophagy in Cancer Cells by Dietary Polyphenols. Antioxidants. 2021; 10(1):123. https://doi.org/10.3390/antiox10010123
Chicago/Turabian StyleMusial, Claudia, Kamila Siedlecka-Kroplewska, Zbigniew Kmiec, and Magdalena Gorska-Ponikowska. 2021. "Modulation of Autophagy in Cancer Cells by Dietary Polyphenols" Antioxidants 10, no. 1: 123. https://doi.org/10.3390/antiox10010123
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