Natural Compounds in Neurogenesis, Neurodevelopment, and the Attenuation of Neurotoxicity: Insights from Animal Models

Dear Colleagues,

Natural compounds are attracting increasing attention due to their potential to enhance neurogenesis, support neurodevelopment, and attenuate neurotoxicity, as demonstrated in numerous animal model studies. These properties are largely due to their strong antioxidant activity, capable of neutralizing reactive oxygen species and reducing oxidative stress, a major contributor to neuronal damage and brain development impairment. Moreover, many phytochemicals such as flavonoids, alkaloids, terpenoids, and polyphenols have shown the capacity to not only preserve cellular integrity but also modulate key molecular pathways involved in inflammation, neuronal proliferation, differentiation, and synaptic plasticity, improving cognitive functions, supporting brain development and resilience, and offering potential avenues for future neuroprotective strategies.

This Special Issue will publish articles investigating new compounds of both natural and synthetic origin that exhibit antioxidant-mediated neurogenesis and neuroprotective effects and support the maintenance of key components of the nervous system, using both established and emerging animal models.

Dr. Giuseppe Montalbano
Guest Editor

Dr. Kamel Mhalhel
Guest Editor Assistant

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