Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection—3rd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 6

Special Issue Editors


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Guest Editor
1. Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia
2. School of Medicine, Catholic University of Croatia, 10000 Zagreb, Croatia
Interests: neuroprotection; neurotoxicity; neurodegenerative diseases; oxidative stress; polyphenols; neuropharmacology
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Special Issue Information

Dear Colleagues,

Following the success of our previous editions, we are pleased to announce the third edition of this Special Issue, “Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection—3rd Edition.” This Special Issue continues to focus on compounds with antioxidative properties and their ability to attenuate oxidative stress, modulate redox-sensitive signaling pathways, and promote neuronal survival.

Oxidative stress is a key contributor to neuronal dysfunction and degeneration in various neurological diseases. Considerable progress has been made in understanding how antioxidative agents influence intracellular pathways involved in oxidative injury, such as the Nrf2/ARE pathway, MAPK signaling (ERK, JNK, p38), NF-κB activity, mitochondrial pathways, and mechanisms regulating apoptosis and autophagy. Nevertheless, important questions remain about how different compounds, both natural and synthetic, interact with these pathways and restore redox balance under diverse cellular conditions.

We also welcome studies that shed light on cellular conditions (such as metal dyshomeostasis) in which traditionally antioxidative compounds may exhibit prooxidative effects, ultimately influencing neuronal survival.  Such insights can provide valuable context for interpreting compound-specific actions and understanding their full range of biological activities. These contributions will support ongoing efforts to advance therapeutic strategies for neuroprotection.

We look forward to your valuable contributions to this Special Issue.

Dr. Maja Jazvinšćak Jembrek
Dr. Josipa Vlainić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroprotection
  • neurotoxicity
  • antioxidative vs. prooxidative activity
  • antioxidant capacity
  • signaling pathways
  • redox metals
  • apoptosis
  • ferroptosis
  • cuproptosis
  • autophagy

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Published Papers

This special issue is now open for submission.
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